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首页> 外文期刊>RSC Advances >Simultaneous detection of l-aspartic acid and glycine using wet-chemically prepared Fe3O4@ZnO nanoparticles: real sample analysis
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Simultaneous detection of l-aspartic acid and glycine using wet-chemically prepared Fe3O4@ZnO nanoparticles: real sample analysis

机译：使用湿化化学制备的Fe3O4 ZnO纳米粒子同时检测L-天冬氨酸和甘氨酸：真实样品分析

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An easy and reliable wet-chemical method was used to synthesize iron oxide doped zinc oxide nanoparticles (Fe _(3) O _(4) @ZnO NPs) at a low-temperature under alkaline medium. The electrochemical characteristics of Fe _(3) O _(4) @ZnO NPs were investigated by using different electrochemical techniques such as UV-vis, FTIR, XRD, FESEM, XEDS, and XPS. A sensor was fabricated by deposition of a thin covering of Fe _(3) O _(4) @ZnO NPs onto a flat dried glassy carbon electrode (GCE) with a polymer matrix with conducting characteristics (Nafion, Nf). L -Aspartic acid and glycine were detected simultaneously by using the modified GCE/Fe _(3) O _(4) @ZnO NPs/Nf sensor in enzyme free conditions. Calibration curves were found to be linear for L -aspartic acid ( R ~(2) = 0.9593) and glycine ( R ~(2) = 0.8617) over a broad range of detected bio-molecule concentration (100.0 pM to 100.0 mM). The analytical sensing parameters, for example sensitivity, linear dynamic range (LDR), limit of detection (LOD), and limit of quantification (LOQ), of the proposed sensor (GCE/Fe _(3) O _(4) @ZnO NPs/Nf) were calculated at two potentials (+0.4 V and +0.7 V) from the calibration plot for L -aspartic acid (126.58 pM μM ~(?1) cm ~(2) , 100.0 pM to 10.0 μM, ≈97.5 pM, and 325.0 mM) and glycine (316.46 pM μM ~(?1) cm ~(2) , 1.0 μM to 1.0 mM, ≈13.5 pM, and 450.0 mM), respectively, by using a reliable current–voltage ( I – V ) technique. The synthesis of Fe _(3) O _(4) @ZnO NPs by means of a wet-chemical route is a good advancement for the development of doped nanomaterial based sensors from the perspective of enzyme-free detection of biological molecules in health-care areas. This proposed GCE/Fe _(3) O _(4) @ZnO NPs/Nf sensor was used for the particular detection of L -aspartic acid and glycine in real samples (human and rabbit serum and urine) and found to achieve reasonable and accepted results.
机译：一种易于可靠的湿化学方法，用于在碱性介质下的低温下合成氧化铁掺杂的氧化锌氧化锌纳米颗粒（Fe _（3）O _（4））。通过使用不同的电化学技术，研究了Fe _（3）O _（4）@ZnO NPS的电化学特性，例如UV-Vis，FTIR，XRD，FESEM，XEDS和XPS。通过将Fe _（3）O _（4）o_（4）的薄覆盖物沉积在具有具有导电特性的聚合物基质（Nafion，NF）上的平坦干燥的玻璃电极（GCE）上来制造传感器。通过在酶无条件下使用改性的GCE / Fe _（3）O _（4）o _（4）o _（4）o _（4）o _（4）o _（4）在酶条件下同时检测L-海藻酸和甘氨酸。发现校准曲线对于L-海藻酸（R〜（2）= 0.9593）和甘氨酸（R〜（2）= 0.8617）的线性，在广泛的检测到的生物分子浓度（100.0pm至100.0mm）上。分析感测参数，例如灵敏度，线性动态范围（LDR），检测限（LOD），以及所提出的传感器的限制（LOQ）（GCE / FE _（3）O _（4）@Zno） NPS / NF）以来自L-海藻酸的校准图（126.58μm〜（α1）cm〜（2），100.0pm至10.0μm，≈97.5的校准图以两个电位（+0.4V和+ 0.7V）计算。 PM和325.0 mm）和甘氨酸（316.46mmμm〜（Δ1）cm〜（2），通过使用可靠的电流电压（I - ）分别通过可靠的电流电压（I - v）技术。通过湿化学途径合成Fe _（3）O _（4）@ZnO NPS是从健康中无酶检测的酶检测的视角下发育掺杂的纳米材料传感器的良好进展护理地区。这提出的GCE / Fe _（3）O _（4）o _（4）@ZnO NPS / NF传感器用于实际样品（人和兔血清和尿液中的L-海藻酸和甘氨酸的特定检测，发现达到合理和接受的结果。

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