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首页> 外文期刊>RSC Advances >Simultaneous detection of l-aspartic acid and glycine using wet-chemically prepared Fe3O4@ZnO nanoparticles: real sample analysis
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Simultaneous detection of l-aspartic acid and glycine using wet-chemically prepared Fe3O4@ZnO nanoparticles: real sample analysis

机译：使用湿化化学制备的Fe3O4 ZnO纳米粒子同时检测L-天冬氨酸和甘氨酸：真实样品分析

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摘要

An easy and reliable wet-chemical method was used to synthesize iron oxide doped zinc oxide nanoparticles (Fe3O4@ZnO NPs) at a low-temperature under alkaline medium. The electrochemical characteristics of Fe3O4@ZnO NPs were investigated by using different electrochemical techniques such as UV-vis, FTIR, XRD, FESEM, XEDS, and XPS. A sensor was fabricated by deposition of a thin covering of Fe3O4@ZnO NPs onto a flat dried glassy carbon electrode (GCE) with a polymer matrix with conducting characteristics (Nafion, Nf). l-Aspartic acid and glycine were detected simultaneously by using the modified GCE/Fe3O4@ZnO NPs/Nf sensor in enzyme free conditions. Calibration curves were found to be linear for l-aspartic acid (R-2 = 0.9593) and glycine (R-2 = 0.8617) over a broad range of detected bio-molecule concentration (100.0 pM to 100.0 mM). The analytical sensing parameters, for example sensitivity, linear dynamic range (LDR), limit of detection (LOD), and limit of quantification (LOQ), of the proposed sensor (GCE/Fe3O4@ZnO NPs/Nf) were calculated at two potentials (+0.4 V and +0.7 V) from the calibration plot for l-aspartic acid (126.58 pM mu M-1 cm(2), 100.0 pM to 10.0 mu M, approximate to 97.5 pM, and 325.0 mM) and glycine (316.46 pM mu M-1 cm(2), 1.0 mu M to 1.0 mM, approximate to 13.5 pM, and 450.0 mM), respectively, by using a reliable current-voltage (I-V) technique. The synthesis of Fe3O4@ZnO NPs by means of a wet-chemical route is a good advancement for the development of doped nanomaterial based sensors from the perspective of enzyme-free detection of biological molecules in health-care areas. This proposed GCE/Fe3O4@ZnO NPs/Nf sensor was used for the particular detection of l-aspartic acid and glycine in real samples (human and rabbit serum and urine) and found to achieve reasonable and accepted results.
机译：易于可靠的湿化学方法用于在碱性介质下的低温下合成氧化铁掺杂的氧化锌氧化锌纳米颗粒（Fe3O4 ZnO NPS）。通过使用不同的电化学技术（如UV-Vis，FTIR，XRD，FESEM，XED和XPS）来研究Fe3O4 @ ZnO NP的电化学特征。通过将Fe3O 4 ZnO NP的薄覆盖物沉积在具有导电特性的聚合物基质（Nafion，NF）上的平坦干燥玻璃电极（GCE）上，通过将Fe3O 4 @ ZnO NPS的薄覆盖物沉积来制造传感器。通过在酶无条件下使用改性的GCE / Fe3O4 ZnO NPS / NF传感器同时检测L-天冬氨酸和甘氨酸。发现校准曲线对于L-天冬氨酸（R-2 = 0.9593）和甘氨酸（R-2 = 0.8617）的甘氨酸线性（R-2 = 0.8617）在宽范围内被检测到的生物分子浓度（100.0pm至100.0mm）。在两个电位下计算分析感测参数，例如灵敏度，线性动态范围（LDR），检测极限（LOD）和量化限制（LOQ）的限制（GCE / FE3O4 @ ZnO NPS / NF） （+0.4 v和+ 0.7 v）从L-天冬氨酸的校准图（126.58mm mu m-1 cm（2），100.0pm至10.0 mu m，近似为97.5 pm和325.0 mm）和甘氨酸（316.46通过使用可靠的电流 - 电压（IV）技术，PM Mu M-1cm（2），1.0μm至1.0 mm，近似为13.5μm和450.0mm）。通过湿化学途径合成Fe3O4 @ ZnO NPS是从医疗区免疫生物分子的无酶检测的角度来发展掺杂纳米材料的传感器的良好进展。这提出的GCE / Fe3O4 @ ZnO NPS / NF传感器用于实际样品（人和兔血清和尿液中L-天冬氨酸和甘氨酸的特定检测，并发现达到合理和可接受的结果。

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  • 来源
    《RSC Advances》 |2020年第33期|共14页
  • 作者

    Hussain Mohammad Musarraf; Asiri Abdullah M.; Rahman Mohammed M.;

  • 作者单位

    King Abdulaziz Univ Fac Sci Chem Dept POB 80203 Jeddah 21589 Saudi Arabia;

    King Abdulaziz Univ Fac Sci Chem Dept POB 80203 Jeddah 21589 Saudi Arabia;

    King Abdulaziz Univ Fac Sci Chem Dept POB 80203 Jeddah 21589 Saudi Arabia;

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  • 正文语种 eng
  • 中图分类 化学;
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