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首页> 外文期刊>RSC Advances >LingZhi oligopeptides amino acid sequence analysis and anticancer potency evaluation
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LingZhi oligopeptides amino acid sequence analysis and anticancer potency evaluation

机译：灵芝寡肽氨基酸序列分析和抗癌效力评估

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LingZhi ( Ganoderma lucidum ) has been used as a therapeutic agent for decades, but the antitumor potency of LingZhi oligopeptides (LZOs) was not well explored. In current study, ten novel LZO amino acid sequences were identified, and anticancer potency was evaluated. We found that LZO-3 [EGHGF] significantly triggered A549 cell apoptosis via mitochondrial dysregulation, as evidenced by caspases activation, mitochondrial membrane potential collapse, Bcl-2/Bax ratio alteration, and cytochrome c release. Further, the down-regulation of Trx/TrxR reductase and the improvement of the MDM2/p53 state also contributed to the LZO-3-induced cell apoptosis. Notably, our findings provide evidence for the novel potency of LZOs, which could be developed as promising chemotherapeutic agents against lung cancer.
机译：Lingzhi（Ganoderma lucidum）已被用作治疗剂数十年，但Lingzhi寡肽（LZOS）的抗肿瘤效力并不熟练。在目前的研究中，鉴定了十种新的LZO氨基酸序列，评价抗癌效力。我们发现LZO-3 [eGHGF]通过线粒体渗透测定显着触发A549细胞凋亡，如Caspases激活，线粒体膜电位塌陷，B​​cl-2 / Bax比改变和细胞色素C释放所证明。此外，TRX / TRXR还原酶的下调和MDM2 / P53状态的改善也有助于LZO-3诱导的细胞凋亡。值得注意的是，我们的研究结果为溶胶的新效力提供了一种效力，这可以作为对抗肺癌的有前途的化学治疗剂来发展。

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