Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity

Ana Carolina Ruberte; Carlos Aydillo; Arun K. Sharma; Carmen Sanmartín; Daniel Plano

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Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity

机译：Vilsmeier试剂，NaHSE和双氯芬酸氯化物：一种新型Selenoinolinone的单罐合成，具有效率的抗癌活性

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An effective and straightforward synthesis of 3-seleno functionalized indolinone ( 5 ) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.

机译：介绍了涉及Vilsmeier试剂的3-硒官能化的3-硒官能化吲哚酮（5）的有效和直接合成。同样，还确定了通过使用氢化物实现具有优异产率的双氯芬酰胺的方法。化合物5在NCI-60面板中的大多数细胞系中表现出令人印象深刻的生长抑制，特别是抗抗性乳腺癌细胞。

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《RSC Advances》 |2020年第63期|共5页
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Ana Carolina Ruberte; Carlos Aydillo; Arun K. Sharma; Carmen Sanmartín; Daniel Plano;
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1. One-pot Vilsmeier reagent-mediated multicomponent reaction: A direct synthesis of oxazolones and Erlenmeyer azlactones from carboxylic acids [J] . Fadavi Abdulhamid, Zarei Maaroof Comptes Rendus Chimie . 2018,第1期

机译：一锅vilsmeier试剂介导的多组分反应：从羧酸的直接合成恶唑酮和Erlenmeyer azlactones
2. Tetrachlorosilane–Zinc Chloride as a New Potent Binary Reagent for One-Pot, Three-Component Synthesis of Mannich-Type Products [J] . Doria S. Badawy, Ebrahim Abdel-Galil, Ezzat M.Kandeel, Phosphorus, Sulfur, and Silicon and the Related Elements . 2009,第11期

机译：四氯硅烷-氯化锌是一种新型的强效二元试剂，可用于曼尼希型产品的一锅，三组分合成
3. Novel Synthetic Method for the Vilsmeier-Haack Reagent and Green Routes to Acid Chlorides, Alkyl Formates, and Alkyl Chlorides [J] . Yoshikazu Kimura, Daisuke Matsuura International journal of organic chemistry . 2013,第3期

机译：Vilsmeier-Haack试剂的新型合成方法和绿色路线，可生成酸性氯化物，烷基甲酸酯和烷基氯
4. Octapeptide Analogs of Somatostatin Containing alpha,alpha-Dialkylated Amino Acids with Potent Anticancer Activity [C] . Sudhanand Prasad, Archna Mathur, Neena Gupta American Peptide Symposium . 2006

机译：含有α-二烷基化氨基酸的生长抑制素的八肽类似物，具有效率的抗癌活性
5. 1. Reduction of Tertiary Benzamides to Benzaldehydes by an in situ-Generated Schwartz Reagent (Cp2 Zirconium (Hydrogen)Chloride); Formal Synthesis of Lysergic Acid. 2. Ru-Catalyzed Amide-Directed Aryl Carbon-Hydrogen, Carbon-Nitrogen and Carbon-Oxygen Bond Functionalizations: C-B Formation, Carbon-Carbon Suzuki Cross Coupling and Hydrodemethoxylation [D] . Zhao, Yigang 2011

机译：1.通过原位生成的Schwartz试剂（Cp2氯化锆（氢）氯化物）将叔苄酰胺还原为苯甲醛；麦角酸的正式合成。 2. Ru催化的酰胺基芳烃碳氢，碳氮和碳氧键功能化：C-B形成，碳-碳铃木交叉偶联和加氢脱甲氧基化
6. One-Pot Synthesis of Sulfur-Doped TiO2/Reduced Graphene Oxide Composite (S-TiO2/rGO) with Improved Photocatalytic Activity for the Removal of Diclofenac from Water [O] . Marin Kovačić, Klara Perović, Josipa Papac, 2020

机译：一锅法合成硫掺杂TiO2 /还原氧化石墨烯复合材料（S-TiO2 / rGO）光催化活性提高可从水中去除双氯芬酸。
7. Novel Synthetic Method for the Vilsmeier-Haack Reagent and Green Routes to Acid Chlorides, Alkyl Formates, and Alkyl Chlorides [O] . Yoshikazu Kimura, Daisuke Matsuura 2013

机译：vilsmeier-haack试剂和绿色途径对酰氯，烷基甲酸酯和烷基氯化物的新型合成方法

Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity

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