Ethanol promoted titanocene Lewis acid catalyzed synthesis of quinazoline derivatives

Yanlong Luo; Ya Wu; Yunyun Wang; Huaming Sun; Zunyuan Xie; Weiqiang Zhang; Ziwei Gao

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Ethanol promoted titanocene Lewis acid catalyzed synthesis of quinazoline derivatives

机译：乙醇促进钛烯酮酸催化合成喹唑啉衍生物

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An efficient catalytic system involving in situ activation of kinetically inert titanocene dichloride with alcoholic solvent for the synthesis of quinazoline derivatives was developed. 1 mol% Cp _(2) TiCl _(2) at 30 °C afforded 17 examples of quinazoline derivatives with yields of 95–98% in 7–12 minutes. Mechanistic experiments using in situ NMR and HRMS established that the coordination of ethanol to the titanocene moiety released the catalytic species [Cp _(2) Ti(OCH _(2) CH _(3) ) _(2) ].

机译：开发了一种有效的催化系统，其涉及用于合成喹唑啉衍生物的含酒精溶剂的动力学惰性二氧化钛酰基二氯化物。在30℃下1mol％CP _（2）TiCl _（2）得到17个喹唑啉衍生物的实施例，产率为95-98％，在7-12分钟内。使用原位NMR和HRMS的机械实验确定了乙醇与钛烯部分的协调释放出催化物质[CP _（2）Ti（OCH _（2）CH_（3））_（2）]。

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《RSC Advances》 |2016年第70期|共4页
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Yanlong Luo; Ya Wu; Yunyun Wang; Huaming Sun; Zunyuan Xie; Weiqiang Zhang; Ziwei Gao;
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1. Ethanol promoted titanocene Lewis acid catalyzed synthesis of quinazoline derivatives [J] . Luo Yanlong, Wu Ya, Wang Yunyun, RSC Advances . 2016,第70期

机译：乙醇促进的钛茂路易斯酸催化合成喹唑啉衍生物
2. Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives [J] . Fang-Peng Hu, Xin-Feng Cui, Guo-Qiang Lu, Organic & biomolecular chemistry . 2020,第23期

机译：基础促进的路易斯酸催化喹唑啉衍生物的合成
3. Iodine-catalyzed synthesis of 5H-phthalazino[1,2-b]quinazoline and isoindolo[2,1-a]quinazoline derivatives via a chemoselective reaction of 2-aminobenzohydrazide and 2-formylbenzoic acid in ionic liquids [J] . Jin Rong-Zhang, Zhang Wen-Ting, Zhou Yu-Jing, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2016,第23期

机译：通过2-氨基苯甲酰肼和2-甲酰基苯甲酸在离子液体中的化学选择性反应，碘催化5H-酞嗪[1,2-b]喹唑啉和异吲哚[2,1-a]喹唑啉衍生物的合成
4. Lewis Acid-Catalyzed Synthesis of Cyclic Carbamates from N-Boc- Protected Aminals and Alkynes [C] . Kento Yasumoto, Taichi Kano, Keiji Maruoka 日本化学会春季年会講演予稿集 . 2018

机译：Lewis酸催化的N- Boc-受芳基和炔烃的环状氨基甲酸酯的合成
5. THE MECHANISM OF LEWIS ACID CATALYZED ENE REACTIONS. LEWIS ACID CATALYZED INTER- AND INTRAMOLECULAR (2+2) CYCLOADDITIONS OF CONJUGATED ALLENIC ESTERS TO ALKENES. THE REGIOCHEMISTRY OF TRIETHYLAMINE DEPROTONATION OF ALPHA, BETA-UNSATURATED ACID CHLORIDES TO FORM VINYLKETENES. ATTEMPTED SYNTHESIS OF ALPHA-BOURBONENE. [D] . RON, EYAL. 1987

机译：路易斯酸催化的烯反应的机理。路易斯酸将共轭的烯丙基酯间和分子内（2 + 2）的循环负载成烯烃。乙酰胺，β-不饱和酸氯化物形成乙烯基酮的三乙胺质子化反应的区域化学。尝试合成Alpha-Bourbonene。
6. Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives [O] . Meredeth A. McGowan, Camille Z. McAvoy, Stephen L. Buchwald -1

机译：脒的钯催化的N-单芳基化和喹唑啉衍生物的一锅法合成
7. Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines [O] . Pandula T. Kirinde Arachchige, Chae S. Yi 2019

机译：通过配体促进的钌催化的脱氢和2-氨基苯基酮和2-氨基苯甲酰胺与胺的促甲喹唑啉酮衍生物的合成喹唑啉酮衍生物

Ethanol promoted titanocene Lewis acid catalyzed synthesis of quinazoline derivatives

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