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首页> 外文期刊>RSC Advances >Methylene blue incorporated mesoporous silica microsphere based sensing scaffold for the selective voltammetric determination of riboflavin
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Methylene blue incorporated mesoporous silica microsphere based sensing scaffold for the selective voltammetric determination of riboflavin

机译：亚甲基蓝掺入介孔二氧化硅微球的基于感应支架，用于核糖蛋白选择性伏安测定

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This study reports the simple, selective and sensitive voltammetric detection of riboflavin (RF) using methylene blue (MB) incorporated sulfonic acid functionalized mesoporous silica microspheres (MSM), represented as MB-SO _(3) H-MSM. MB-SO _(3) H-MSM is synthesized and characterized by spectroscopic and microscopic methods. This material is coated on a glassy carbon (GC) electrode (symbolized as GC/MB-SO _(3) H-MSM) to utilize it in electroanalytical applications. The electrochemical behavior of MB-SO _(3) H-MSM is established using the GC/MB-SO _(3) H-MSM electrode by cyclic voltammetry (CV) and electrochemical impedance spectroscopy techniques. The electrochemical behavior of RF at the GC/MB-SO _(3) H-MSM electrode is also studied by CV. Compared to bare GC and SO _(3) H-MSM coated GC, the GC/MB-SO _(3) H-MSM electrode shows favorable electron transfer kinetics as well as an enhanced and stable electrochemical response of RF. Furthermore CV and differential pulse voltammetry (DPV) are used for the quantitative determination of RF at the GC/MB-SO _(3) H-MSM electrode. The DPV response shows two linear calibration ranges of 10.0 nM to 15.0 μM and 15.0 to 50.0 μM. The detection limit based on the first linear calibration range is calculated as 5.0 nM with a sensitivity of 393.0 μA mM ~(?1) cm ~(?2) . The fabricated sensing scaffold shows an excellent selectivity for RF over other soluble vitamins and interfering ions. The stability, reproducibility and determination of RF in pharmaceutical products are also demonstrated effectively.
机译：本研究报告了使用亚甲基蓝（MB）掺入的磺酸官能化的介孔二氧化硅微球（MSM）的简单，选择性和敏感的伏安检测核黄素（RF），表示为MB-SO_（3）H-MSM。通过光谱和微观方法合成和表征MB-SO _（3）H-MSM。将该材料涂覆在玻璃状碳（GC）电极上（符号为GC / MB-SO_（3）H-MSM）以在电分析应用中使用它。使用循环伏安法（CV）和电化学阻抗谱技术，使用GC / MB-SO_（3）H-MSM电极建立MB-SO_（3）H-MSM的电化学行为。 CV还研究了GC / MB-SO_（3）H-MSM电极的RF的电化学行为。与裸GC等_（3）H-MSM涂覆的GC，GC / MB-SO_（3）H-MSM电极显示出有利的电子转移动力学以及RF的增强且稳定的电化学响应。此外，CV和差分脉冲伏安法（DPV）用于定量测定GC / MB-SO_（3）H-MSM电极的RF。 DPV响应显示两个线性校准范围为10.0nm至15.0μm，15.0至50.0μm。基于第一线性校准范围的检测极限计算为5.0nm，灵敏度为393.0μAmm〜（α1）cm〜（？2）。制造的传感支架显示出RF在其他可溶性维生素和干扰离子上的优异选择性。还有效地证明了药物产品中RF的稳定性，再现性和测定。

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