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首页> 外文期刊>RSC Advances >Synthesis, crystal structures, and in vitro anticancer properties of new N-heterocyclic carbene (NHC) silver(i)- and gold(i)/(iii)-complexes: a rare example of silver(i)–NHC complex involved in redox transmetallation
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Synthesis, crystal structures, and in vitro anticancer properties of new N-heterocyclic carbene (NHC) silver(i)- and gold(i)/(iii)-complexes: a rare example of silver(i)–NHC complex involved in redox transmetallation

机译：新型N-杂环（NHC）银（I）银（I） - 和金（I）/（III）的合成，晶体结构和体外抗癌性质 - 兼容：稀有氧化还原的银（I）-NHC复合物的罕见实施例传输组合

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A series of cationic, linearly coordinated silver( I )– ( 4–6 ) and gold( I )/( III )–NHC (NHC = N-heterocyclic carbene) ( 7–9 ) complexes of (benz)imidazol-2-ylidene ligands was prepared and successfully characterized. Complexes 4–6 were prepared by in situ deprotonation of azolium salts and 7–9 by NHC transfer from their respective silver( I ) complexes. All new compounds were characterized by elemental analysis and ~(1) H, ~(13) C NMR, and FTIR spectroscopy techniques, and four of the complexes were unambiguously characterized by single-crystal X-ray diffraction method. Results of structural studies on single crystals of 5a , 6 , and 8 revealed a linear coordination geometry about the metal center, whereas gold( III ) in complex 7 had a consistent square-planar geometry. The reaction of complex 4 with gold( I ) source formed a gold( III )–NHC complex following redox transmetallation. In all these cases, metal?H and π?π stacking interactions were observed, which affected the C _(carbene) –M–C _(carbene) bond angle. Preliminary anticancer activities of all new compounds were also studied in vitro against four human derived cancer cell lines by MTT assay method. Cationic silver( I ) complexes displayed better anticancer potentials than their gold( I ) counterparts. In particular, gold( III ) complex displayed superior activity, with IC _(50) values at low-micro and nanomolar levels; thus, this complex showed superior selectivity toward all four tested cancer cell lines.
机译：一系列阳离子，线性协调的银（I） - （4-6）和金（I）/（III）-NHC（NHC = N-杂环碳切菜）（7-9）复合物（苯兹）咪唑-2-制备ylidene配体并成功表征。通过从其各自的银（I）复合物中的NHC转移来制备复合物4-6。所有新化合物的特征在于元素分析，〜（1）H，〜（13）C NMR和FTIR光谱技术，并通过单晶X射线衍射方法明确地表征四种复合物。在5A，6和8的单晶的结构研究结果显示了关于金属中心的线性配位几何形状，而复合物7中的金（III）具有一致的方形平面几何形状。复合物4与金（I）源的反应形成氧化还原透射后的金（III）-NHC复合物。在所有这些情况下，观察到金属αH和π？π堆叠相互作用，其影响了C _（卡宾）-C-C _（卡贝烯）键角。通过MTT测定法在体外研究所有新化合物的初步抗癌活动。通过MTT测定法在四种人衍生的癌细胞系中进行体外研究。阳离子银（i）复合物显示比他们的黄金（i）对应的更好的抗癌潜力。特别是，金（III）复合物在低微米和纳摩尔水平下具有IC _（50）值的优异活动;因此，这种复合物对所有四种测试的癌细胞系显示出优异的选择性。

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