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首页> 外文期刊>RSC Advances >Synthesis, crystal structures, and in vitro anticancer properties of new N-heterocyclic carbene (NHC) silver(I)- and gold(I)/(III)-complexes: a rare example of silver(I)-NHC complex involved in redox transmetallation
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Synthesis, crystal structures, and in vitro anticancer properties of new N-heterocyclic carbene (NHC) silver(I)- and gold(I)/(III)-complexes: a rare example of silver(I)-NHC complex involved in redox transmetallation

机译：新型N杂环卡宾（NHC）银（I）-和金（I）/（III）复合物的合成，晶体结构和体外抗癌特性：涉及氧化还原的银（I）-NHC复合物的罕见例子金属化

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A series of cationic, linearly coordinated silver(I)- (4-6) and gold(I)/(III)-NHC (NHC = N-heterocyclic carbene) (7-9) complexes of (benz)imidazol-2-ylidene ligands was prepared and successfully characterized. Complexes 4-6 were prepared by in situ deprotonation of azolium salts and 7-9 by NHC transfer from their respective silver(I) complexes. All new compounds were characterized by elemental analysis and H-1, C-13 NMR, and FTIR spectroscopy techniques, and four of the complexes were unambiguously characterized by single-crystal X-ray diffraction method. Results of structural studies on single crystals of 5a, 6, and 8 revealed a linear coordination geometry about the metal center, whereas gold(III) in complex 7 had a consistent square-planar geometry. The reaction of complex 4 with gold(I) source formed a gold(III)-NHC complex following redox transmetallation. In all these cases, metal center dot center dot center dot H and pi center dot center dot center dot pi stacking interactions were observed, which affected the C-carbene-M-C-carbene bond angle. Preliminary anticancer activities of all new compounds were also studied in vitro against four human derived cancer cell lines by MTT assay method. Cationic silver(I) complexes displayed better anticancer potentials than their gold(I) counterparts. In particular, gold(III) complex displayed superior activity, with IC50 values at low-micro and nanomolar levels; thus, this complex showed superior selectivity toward all four tested cancer cell lines.
机译：（苯）咪唑-2-的一系列阳离子，线性配位的银（I）-（4-6）和金（I）/（III）-NHC（NHC = N-杂环卡宾）（7-9）配合物制备亚烷基配体并成功表征。配合物4-6是通过偶氮盐原位去质子化而制备的，而7-9是通过NHC从各自的银（I）配合物中转移而制得的。所有新化合物均通过元素分析，H-1，C-13 NMR和FTIR光谱技术进行了表征，其中四种配合物均通过单晶X射线衍射法进行了明确表征。对5a，6和8的单晶进行结构研究的结果表明，金属中心周围呈线性配位几何，而配合物7中的金（III）具有一致的正方形平面几何。配合物4与金（I）源的反应在氧化还原金属转移作用之后形成金（III）-NHC配合物。在所有这些情况下，观察到金属中心点中心点中心点H和pi中心点中心点中心点pi的堆叠相互作用，这影响了C-卡宾-M-C-卡宾键的结合角。还通过MTT测定法在体外研究了所有新化合物对四种人类衍生癌细胞系的初步抗癌活性。阳离子银（I）配合物显示出比其金（I）对应物更好的抗癌潜力。特别是，金（III）配合物表现出优异的活性，低微纳摩尔浓度的IC50值;因此，该复合物对所有四个测试的癌细胞系均显示出优异的选择性。

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