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首页> 外文期刊>RSC Advances >Tailor-made poly(l-lactide)/poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds prepared via high-pressure compression molding/salt leaching
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Tailor-made poly(l-lactide)/poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds prepared via high-pressure compression molding/salt leaching

机译：定制的聚（L-丙交酯）/聚（丙交酯 - 共乙酰胺）/羟基磷灰石复合支架通过高压压缩成型/盐浸出制备

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摘要

A significant challenge in bone tissue engineering is the development of biomimetic scaffolds that can meet the requirements of mechanical and degradation properties at the same time. The composite scaffolds comprising poly( L -lactide) (PLLA), poly(lactide- co -glycolide) (PLGA) and hydroxyapatite (HA) were fabricated by a new method, i.e. , high-pressure compression molding plus salt-leaching technique. The scaffolds obtained show an encouraging improvement in the mechanical performance. The compressive modulus reaches up to 4.64 ± 0.2 MPa, comparable to human cancellous bone (2–10 MPa), offering the possibility to develop load-bearing scaffolds. Furthermore, by adjusting the weight ratio of PLLA to PLGA, the degradation rate, hydrophilicity, and mechanical properties of scaffolds can be fine-tuned. The overall characteristics of porous composite scaffolds are definitely optimal when the mass ratio of PLLA/PLGA is 5?:?5. Its porosity, contact angle, compressive modulus and weight loss at the 12 ~(th) week are 81.7%, 53.13°, 4.64 ± 0.2 MPa and 67.21 ± 3.14%, respectively, satisfying the physiological demands to guide tissue regeneration. Scaffolds with the best comprehensive properties are further utilized for in vitro tests. As presented from the excellent spreading and the high proliferation rate of cells, the design of such tailor-made scaffolds as a function of composition is a convenient strategy to address the specific requirements of the tissue to be regenerated.
机译：骨组织工程中的重大挑战是在仿生支架的发展中，可以同时满足机械和降解性能的要求。通过新方法，即高压压缩成型加盐浸出技术制备了包含聚（L-阶液）（PLLA），聚（丙交酯）（PLLA），聚（丙交酯酰基）和羟基磷灰石（HA）的复合支架。获得的支架显示出令人鼓舞的机械性能的改善。压缩模量高达4.64±0.2MPa，可与人松质骨骼（2-10MPa）相当，提供开发承载支架的可能性。此外，通过调节PLLA对PLGA的重量比，可以微调支架的降解速率，亲水性和机械性能。当PLLA / PLGA的质量比为5时，多孔复合支架的总体特征绝对是最佳的？其孔隙率，接触角，压缩模量和重量损失在12〜（Th）周的81.7％，53.13°，4.64±0.2MPa和67.21±3.14％，满足引导组织再生的生理需求。具有最佳综合性质的支架进一步用于体外测试。如优异的展开和细胞的高增殖率所示，根据组合物的函数设计这种量身定制的支架是一种方便的策略，以解决待再生组织的特定要求。

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