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首页> 外文期刊>RSC Advances >Doxorubicin-loaded ionic liquid–polydopamine nanoparticles for combined chemotherapy and microwave thermal therapy of cancer
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Doxorubicin-loaded ionic liquid–polydopamine nanoparticles for combined chemotherapy and microwave thermal therapy of cancer

机译：加载多柔比星的离子液 - 聚二胺纳米胺，用于组合化疗和微波热疗癌症

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Recently, combinational therapy has been increasingly employed in the treatment of cancer. In this study, hollow polydopamine nanoparticles were developed as favorable biocompatible delivery nanoplatforms for chemotherapy and microwave thermal therapy. By loading polydopamine nanoparticles with ionic liquid, the functionalized polydopamine nanoparticles became chemotherapeutic drug nanocarriers for combinational therapy. The obvious antitumor efficacy of doxorubicin-loaded ionic liquid–polydopamine nanocomposites was demonstrated in in vitro and in vivo experiments for combined chemotherapy and microwave thermal therapy. Moreover, the combination of chemotherapy with microwave thermal therapy applied to cancer therapy based on drug-loaded ionic liquid–polydopamine nanocomposites is a promising therapy for future cancer treatment in clinical applications.
机译：最近，组合治疗越来越多地用于治疗癌症。在该研究中，中空多德米胺纳米粒子被开发为有利的生物相容性递送纳米液相传，用于化疗和微波热疗。通过用离子液体加载聚二胺纳米颗粒，官能化的聚德胺纳米粒子成为组合治疗的化学治疗药物纳米载体。在体外和体内化疗和微波热疗的体外和体内实验中展示了多柔枯蛋白负载离子液 - 多水多水多胺纳米膜复合材料的明显抗肿瘤效果。此外，基于药物负载离子液 - 多水多胺纳米复合材料复合材料对癌症治疗的微波热疗法的化疗的组合是未来临床应用中未来癌症治疗的有希望的治疗。

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