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Copper-catalyzed and iodide-promoted aerobic C–C bond cleavage/C–N bond formation toward the synthesis of amides

机译:铜催化和碘化物促进的有氧C-C键切割/ C-N键形成酰胺的合成

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A copper-catalyzed and iodide-promoted aerobic C–C bond cleavage/C–N bond formation reaction between ketone and simple amine was developed toward the synthesis of amides, which are useful synthetic intermediates in organic synthesis and important skeletons of biologically active molecules. Notably, the reaction conditions are very mild, and preliminary mechanistic investigations indicate that molecular oxygen might be involved in the C–C bond cleavage process.
机译:酮催化和碘化物促进的有氧C-C键裂解/ C-N键形成反应在酮类和简单胺之间的合成,其是有机合成中有用的合成中间体和生物活性分子的重要骨架。值得注意的是,反应条件非常温和,并且初步机械研究表明分子氧可能参与C-C键切割过程。

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