d-Glucose based syntheses of β-hydroxy derivatives of l-glutamic acid, l-glutamine, l-proline and a dihydroxy pyrrolidine alkaloid

K. S. Ajish Kumar; Subrata Chattopadhyay

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d-Glucose based syntheses of β-hydroxy derivatives of l-glutamic acid, l-glutamine, l-proline and a dihydroxy pyrrolidine alkaloid

机译：L-谷氨酸，L-谷氨酰胺，L-脯氨酸和二羟基吡咯烷生物碱的β-羟基衍生物的D-葡萄糖基合成

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The β-hydroxy derivatives of L -glutamic acid, L -glutamine and L -proline, useful for peptide/protein studies, were synthesized starting from D -glucose. The C2 carbon in D -glucose provided the carboxylic acid functionality, while the amino and β-hydroxy groups of the amino acids were amenable from the C3 and C4 hydroxy groups of the sugar, respectively. The key intermediate with appropriate carbon framework of the target molecules was constructed by homologation of a suitable azido- D -glucofuranose derivative using the Arndt–Eistert reaction.

机译：从D葡萄糖开始合成L-乙醇，L-谷氨酰胺和L-脯氨酸，可用于肽/蛋白质研究的β-羟基衍生物。 D-葡糖中的C2碳提供羧酸官能团，而氨基酸的氨基和β-羟基分别可从C3和C4羟基的糖的C3和C4羟基。通过使用ArnDT-ESTERT反应的合适的αzido-dglucofuranose衍生物的同源构建靶分子的关键中间体。

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《RSC Advances》 |2015年第25期|共10页
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K. S. Ajish Kumar; Subrata Chattopadhyay;
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1. D-Glucose based syntheses of beta-hydroxy derivatives of L-glutamic acid, L-glutamine, L-proline and a dihydroxy pyrrolidine alkaloid [J] . Kumar K. S. Ajish, Chattopadhyay Subrata RSC Advances . 2015,第25期

机译：基于葡萄糖的L-谷氨酸，L-谷氨酰胺，L-脯氨酸和二羟基吡咯烷生物碱的β-羟基衍生物合成
2. Synthesis and characterization of four new manganese(III) complexes and amino acid (L-aspartic acid, L-asparagine, L-glutamic acid, L-glutamine) Schiif bases [J] . Iffet Sakiyan Transition Metal Chemistry . 2007,第1期

机译：四种新型锰（III）配合物和氨基酸（L-天冬氨酸，L-天冬酰胺，L-谷氨酸，L-谷氨酰胺）Schiif碱的合成与表征
3. Synthesis and characterization of four new manganese(III) complexes and amino acid (L-aspartic acid, L-asparagine, L-glutamic acid, L-glutamine) Schiff bases [J] . ?ffet ?ak?yan Transition Metal Chemistry . 2007,第1期

机译：四种新型锰（III）配合物和氨基酸（L-天冬氨酸，L-天冬酰胺，L-谷氨酸，L-谷氨酰胺）席夫碱的合成与表征
4. Stereoselective Syntheses of β-Hydroxy Amino Acids by Isonitrile Aldol Reaction [C] . Kazuma Fuku, Yoko Yasuno, Tetsuro Shinada 日本化学会春季年会講演予稿集 . 2018

机译：异腈醛醇反应的β-羟基氨基酸的立体选择合成
5. I. SPIRO ASYMMETRIC INDUCTION: SYNTHESIS OF OPTICALLY PURE ALPHA-HYDROXY- AND ALPHA,BETA-DIHYDROXY ACID DERIVATIVES. II. OXIDATIVE ELECTROLYSIS OF GAMMA-KETAL CYCLOHEXANECARBOXYLIC ACIDS: TOTAL SYNTHESIS OF MALYNGOLIDE [D] . CHENG, MINN-CHANG 1987

机译：I.螺线不对称诱导：光学纯的α-羟基和α，β-二羟基乙酸衍生物的合成。二。 γ-羟基环己烷羧酸的氧化电解：丙二醛的合成
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机译：烯丙基化吲哚生物碱的统一方法：（–）-17-羟基-柠檬醛素B（+）-十八酸A和（+）-诺酰胺I的总合成
7. Studies on the Syntheses of Condensed Indole-4, 7-dione Derivatives. III. Syntheses of Pyrrole-2-acetic Acid Derivatives using gamma;-Amino-n-butyric Acid and gamma;-Amino-beta;-hydroxy-n-butyric Acid as a Synthon of Pyrrole [O] . MASAO OKAMOTO, SHUNSAKU OHTA, ATSUHIKO TSUJIMURA, 1982

机译：缩合吲哚-4,7-二酮衍生物的合成研究。 III。使用γ-氨基 - 正丁酸和γ-氨基-β-羟基 - 丁酸作为吡咯合成的吡咯-2-乙酸衍生物合成
8. Synthesis of alpha-Hydroxy-alpha-Amino Acids and Ergot Alkaloids [R] . Liwschitz, Y. 1967

机译：α-羟基-α-氨基酸和麦角生物碱的合成

d-Glucose based syntheses of β-hydroxy derivatives of l-glutamic acid, l-glutamine, l-proline and a dihydroxy pyrrolidine alkaloid

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