...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Arginase and Procalcitonin Promising Biomarkers for Early Diagnosis of Sepsis
【24h】

Arginase and Procalcitonin Promising Biomarkers for Early Diagnosis of Sepsis

机译：Aginase和ProCalcitonin有希望的生物标志物，用于早期诊断败血症

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Sepsis remains a major cause of death in criticallyill patients in Indian population because of high susceptibilitytowards infectious diseases in the world. Procalcitonin (PCT) is awell-studied marker in foreign countries but needs to be establishedin Indian population. In the last few years, importance of Arginaseas a marker of immunity has also increased exceptionally, becausethis enzyme is essentially involved in different inflammatoryprocesses. Keeping these facts in mind PCT and Arginase wereevaluated for their utility as markers to diagnose sepsis.Aim: To evaluate Arginase and PCT as biomarkers for earlydiagnosis of sepsis.Materials and Methods: Hundred adult patients (age >18years) with Systemic Inflammatory Response Syndrome (SIRS)attending BJ Medical College which is affiliated with SassoonGeneral Hospital (Pune, Maharashtra, India) during May 2012-July 2015 were incorporated in the study. Age n sex-matched of100 samples healthy controls were also collected. Arginase wasestimated by Roman and Ray method and PCT by Enzyme-linkedImmunosorbent Assay Kit (ELISA) method. Unpaired t-test wasdone to compare the mean biomarker levels between the casesand controls. The Area Under Curve (AUC) was calculated usingReceiver Operating Curve (ROC). All the data analysis was set at95% Confidence Interval (CI) and value p<0.05 are statisticallysignificant. Data analysis was done using Statistical Packagefor Social Sciences (SPSS) version 21.0.Results: In the study, a significant increase was observed inthe levels of arginase (p<0.01) and PCT (p<0.01) in cases ascompared to controls. ROC curves were plotted to find out thecut-offs of arginase (4.6 IU/L) and PCT (0.04 ng/mL) to checkthe diagnostic efficacy of both the biomarkers.Conclusion: Serum PCT and arginase offers a high level ofaccuracy than other currently available tests and hence can behelpful in the management of sepsis. In addition to this apartfrom high sensitivity and specificity arginase estimation is costeffective as compared to PCT.
机译：介绍：由于高易感性在世界上感染性疾病高，败血症仍然是印度人口批评患者的主要原因。 ProCalcitonin（PCT）在国外享受了令人震惊的标记，但需要建立印度人口。在过去的几年中，Arginaseas的重要性免疫的标记也有所增加，因此酶基本上涉及不同的炎症性能。将这些事实保持在MEDE和ARGIN酶作为其实用性作为诊断SEPSIS.AIM：评估氨基酶和PCT作为SEPSIS的早期诊断的生物标志物：全身炎症反应综合征的一百个成年患者（年龄> 18年）（ SIRS）在2012年5月至2015年5月期间，参加了与Sassoongeneral医院（Pune，Maharashtra，India）相关的BJ医学院，于2015年7月载入该研究。还收集了100岁的性别匹配的100个样品健康对照。通过罗马和射线法和PCT通过酶 - LinkedimMunoSorphent试验试剂盒（ELISA）方法令人生畏的氨基酶。未配对的T-试验滴度，以比较案件和对照之间的平均生物标志物水平。计算使用曲线（AUC）下的区域使用receiver操作曲线（ROC）。所有数据分析都设定为95％置信区间（CI），值P <0.05是统计学上的。使用统计包装（SPSS）版本21.0.0.0.0.0.4.在研究中，观察到含有对照组的氨基酶（P <0.01）和PCT（P <0.01）的含量显着增加。绘制ROC曲线以发现氨基酶（4.6 IU / L）和PCT（0.04 ng / ml）的THET-OFF，以检查生物标志物的诊断疗效。结论：血清PCT和Aginase提供高度累计，而不是其他目前可用的累计测试，因此可以在败血症的管理方面是难题的。除此之外，与PCT相比，在高灵敏度和特异性氨基酶估计之外估计是高昂的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号