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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Effect of Hyperthyroidism on the Level of Urinary Neutrophil Gelatinase-Associated Lipocalin and Markers of Kidney Function
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The Effect of Hyperthyroidism on the Level of Urinary Neutrophil Gelatinase-Associated Lipocalin and Markers of Kidney Function

机译：甲状腺功能亢进症对尿中性粒细胞凝胶酶相关脂素和肾功能标志物的影响

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Thyroid hormones affect kidneys in various ways ranging from their development to their functions. Serum and urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) are emerging as the most promising biomarkers for early determination of Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD).Aim: To evaluate the effects of hyperthyroidism (subclinical and overt) on the markers of kidney function.Materials and Methods: In this cross-sectional study, 300 subjects were recruited from May 2015 to June 2018 and divided in three categories of euthyroid, subclinical and overt hyperthyroid subjects. All the subjects were analysed for Thyroid function (Total T3 , T4 , Thyroid Stimulating Hormone (TSH)) and Kidney Function (Serum Urea, Serum Creatinine, Urinary NGAL, estimated Glomerular Filtration Rate (eGFR)).Results: Statistical analysis revealed a significant decrease in serum urea and serum creatinine in both subclinical (17.32±3.51 mg/dL and 0.58±0.13 mg/dL, respectively) and overt hyperthyroid (13.52±2.78 mg/dL and 0.29±0.10 mg/dL, respectively) patients as compared to euthyroids (19.99±5.38 mg/dL and 0.87±0.25 mg/dL, respectively). Urinary NGAL and eGFR were significantly increased in both subclinical (30.24±8.63 ng/mL and 119.57±11.31 mL/min, respectively) and overt hyperthyroid (44.05±13.02 ng/mL and 155.12±19.75 mL/min, respectively) patients as compared to euthyroids (21.94±18.06 ng/mL and 97.97±25.92 mL/min, respectively). A negative correlation of creatinine and positive correlation of urinary NGAL and eGFR with T3 and T4 was observed in both subclinical and overt hyperthyroidism (p<0.05).Conclusion: The study shows that there are negative effects of hyperthyroidism on kidney functions.
机译：甲状腺激素以各种方式影响肾脏，从他们的发展到他们的功能。血清和尿液中性粒细胞凝胶酶相关的脂素（NGAL）是最有前景的生物标志物，用于早期测定急性肾损伤（AKI）和慢性肾病（CKD）。目的：评估甲状腺功能亢进的影响（亚临床和公开的）关于肾功能标记。材料和方法：在这种横断面研究中，从2015年5月至2018年5月开始招募300个科目，并分为三类肠蛋白，亚临床和公开甲状腺素毒物。分析所有受试者的甲状腺功能（总T3，T4，甲状腺刺激激素（TSH））和肾功能（血清尿素，血清肌酐，尿NGAL，估计的肾小球过滤速率（EGFR））。结果：统计分析在亚临床（分别为17.32±3.51mg / dl和0.58±0.13mg / dl，显着甲状腺素（分别为0.58±0.13mg / dl，分别显着降低血清尿素和血清肌酐（分别为甲状腺功能亢进（分别为13.52±2.78mg / dl和0.29±0.10mg / dl）患者与Euthyroids相比（分别为0.87±5.38mg / dl和0.87±0.25 mg / dl）。尿NGAL和EGFR在亚临床（30.24±8.63ng / ml和119.57±11.3.31ml / min）中显着增加，并且显着的甲状腺素（44.05±13.02 ng / ml和155.12±19.75 ml / min）比较对于Euthyroids（21.94±18.06ng / ml和97.97±25.92ml / min）。在亚临床和公开甲状腺功能亢进中观察到肌酐和泌尿NGAL和EGFR与T3与T3的负相关性（P <0.05）。结论：该研究表明甲状腺功能亢进对肾功能的负面影响。

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