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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Epidemiological, Clinical and Paraclinical Characteristics of Childhood Acute Lymphoblastic Leukaemia in Sanaa??a, Yemen
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Epidemiological, Clinical and Paraclinical Characteristics of Childhood Acute Lymphoblastic Leukaemia in Sanaa??a, Yemen

机译：Sanaa儿童急性淋巴细胞白血病儿童急性淋巴细胞白血病的流行病学，临床和髌癌特征，也门

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Acute leukaemia is one of the most common types of cancers among children. There is only restricted number of studies about childhood leukaemia in Yemen, hence the importance of performing this study.Aim: To assess the epidemiological, clinical and para-clinical characteristics of childhood acute lymphoblastic leukaemia in Sanaa??a, Yemen.Materials and Methods: This was a descriptive retrospective study. It included 177 children younger than 15 years with Acute Lymphoblastic Leukaemia (ALL), who were diagnosed in the period from May to September 2011 to 2017 in the Childhood Leukemia Management Center (CLMC) in Sanaa??a, Yemen. The diagnosis was based on clinical characteristics, bone marrow morphology and immunophenotyping. The data was analysed using SPSS program. Chi-square test with Yate correction and Fisher tests were used to identify the significance of associations.Results: Majority of patients 129 (72.8%) were between 1-9 years and male to female ratio was 1.53 to 1. The most common presenting features were fever (89.3%), pallor (89.3%) and bone pain (71.3%). Immunophenotyping was done for 126 patients; 99 (78.6%) had precursor B-cell and 27 (21.4%) had T-cell ALL. Ninety two (52.6%) of patients were classified as standard risk and 83 (47.4%) were high risk; most of them were T-cell ALL. Response to chemotherapy in induction phase was excellent with complete remission rate of 94.2%. Relapse was 16.5%; 62.9% of them were medullary relapses. Mortality during induction was 15.6%. Infection was the most common cause of death (37.8%), followed by haemorrhage (11.1%).Conclusion: ALL is considered a significant health problem in Yemen. It needs high awareness and more attention from the governorate regarding improving the capacities of health facilities on health information, diagnosis and treatment.
机译：急性白血病是儿童中最常见的癌症之一。只有禁止有关也门儿童白血病的研究数量，因此进行这项研究的重要性。目的：评估Sanaa的儿童急性淋巴细胞白血病的流行病学，临床和临床特征，也门。 材料和方法：这是一个描述性回顾性研究。它包括超过15年的儿童，患有急性淋巴细胞白血病（全部），他于2011年5月至2017年9月至2017年在Sanaa的儿童白血病管理中心（CLMC）中被诊断出来?? A，也门。诊断基于临床特征，骨髓形态和免疫蛋白型。使用SPSS程序分析数据。使用Yate校正和Fisher测试的Chi-Square测试用于识别关联的重要性。结果：大多数患者129（72.8％）在1-9岁之间，男性与女性比率为1.53至1.最多常见的呈现特征是发烧（89.3％），Pallor（89.3％）和骨疼痛（71.3％）。 Immunopheotyping是126名患者的; 99（78.6％）具有前体B细胞，27（21.4％）具有T细胞。九十二（52.6％）患者被归类为标准风险，83例（47.4％）风险高;其中大多数是T细胞。对诱导阶段化疗的反应具有94.2％的完全缓解率优异。复发为16.5％;其中62.9％是髓质复发。诱导期间的死亡率为15.6％。感染是最常见的死因（37.8％），其次是出血（11.1％）。结论：所有人都被认为是也门的重大健康问题。它需要高度认识和更多关注省，了解卫生设施对健康信息，诊断和治疗的能力。

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