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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Cardiac Biomarkers in Dengue Myocarditis in a Tertiary Care Hospital in Eastern India
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Evaluation of Cardiac Biomarkers in Dengue Myocarditis in a Tertiary Care Hospital in Eastern India

机译：在印度东部护理医院登革热心肌炎心脏生物标志物的评价

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Dengue, a vector borne viral infection transmitted by Aedes mosquito has recently become a major public health concern in the tropical regions of the world. In addition to the two major life threatening complications- Dengue Haemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS), a variety of cardiac complications have been recognised, the most common being myocarditis.Aim: To study and compare the quantity of different cardiac biomarkers in patients of Dengue Fever with and without myocarditis.Materials and Methods: This was a hospital-based retrospective observational study done in a Tertiary Care Hospital, Kolkata, West Bengal, India from June 2019 to November 2019. Dengue patients with diagnosed myocarditis on day 7 of fever based on electro and echocardiogram changes of left ventricular ejection fraction less than 50% were considered as cases (n=41). Age and sex matched dengue patients with normal electro and echocardiogram changes were considered as control (n=43). After obtaining Institutional Ethics Committee Clearance, laboratory data were collected from samples coded and assayed for markers of acute cardiac myocyte damage such as total Creatine Kinase (CK), CK-Muscle Brain (CK-MB), Troponin T (Trop T) and cardiac failure biomarker N-Terminal pro Brain Natriuretic Peptide (NT-proBNP). Statistical analysis of the data was performed using Statistical Package for Social Sciences (SPSS 20).Results: Cardiac biomarkers CK, CK-MB, Trop T and NT-proBNP levels in cases were higher compared to controls (p-value <0.05). Trop T and NT-proBNP were positively correlated to each other (r-value: 0.44). Trop T changes could also predict significantly the rise in NT-proBNP in circulation (p<0.05).Conclusion: It reconfirmed the need of routine monitoring of cardiac biomarkers in conjunction with other cardiac function tests in early diagnosis and or management of myocarditis, a severe complication of Dengue Viral Infection (DENV).
机译：登革热由伊蚊传播的载体传播病毒感染最近已成为世界热带地区一个主要的公共健康问题。除了两个主要的威胁生命的complications-登革出血热（DHF）和登革休克综合征（DSS），各种心脏并发症的认可，最常见的是心肌炎目的：研究和比较的数量在有和没有心肌炎登革热患者不同心脏标志物的材料和方法：这是一个三级医院，加尔各答，西孟加拉邦，印度做从2019年6月至2019年11月以医院为基础的回顾性观察研究。登革热患者在第7天诊断心肌炎发热的基于左心室射血分数小于50％的电和超声心动图的变化被认为是例（N = 41）。年龄和性别匹配登革热患者与正常电和超声心动图的变化被认为是对照（n = 43）。获得伦理委员会减价后，实验室数据从编码样本收集并测定急性心肌细胞损伤的标记物，例如总肌酸激酶（CK），CK-肌肉脑（CK-MB），肌钙蛋白T（特罗普T）和心失败的生物标志物的N-末端脑利钠肽（NT-proBNP水平）。使用统计软件包社会科学（SPSS 20）进行数据的统计分析的结果：心脏生物标志物CK，CK-MB，特罗普T和NT-proBNP水平的情况下水平高于对照组（p值< 0.05）。特罗普T和NT-proBNP水平呈正相关，以彼此（r值：0.44）。特罗普T改变也可以显著预测在流通的NT-proBNP的上升（P <0.05）的。结论：重新确认的心脏生物标记物的常规监测与在早期诊断和或管理其他心脏功能检查一起使用时的需要心肌炎，登革热病毒感染的严重并发症（DENV）。

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