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首页> 外文期刊>Emerging Infectious Diseases >Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium
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Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium

机译：含有无响应支气管内，比利时的含药抗毒性抗毒性障碍的障碍

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Gallibacterium anatis is an opportunistic pathogen, previously associated with deaths in poultry, domestic birds, and occasionally humans. We obtained G. anatis isolates from bronchoalveolar lavage samples of 10 calves with bronchopneumonia unresponsive to antimicrobial therapy. Collected isolates were multidrug-resistant to extensively drug-resistant, exhibiting resistance against 5-7 classes of antimicrobial drugs. Whole-genome sequencing revealed 24 different antimicrobial-resistance determinants, including genes not previously described in the Gallibacterium genus or even the Pasteurellaceae family, such as aadA23, bla CARB-8 , tet(Y), and qnrD1. Some resistance genes were closely linked in resistance gene cassettes with either transposases in close proximity or situated on putative mobile elements or predicted plasmids. Single-nucleotide polymorphism genotyping revealed large genetic variation between the G. anatis isolates, including isolates retrieved from the same farm. G. anatis might play a hitherto unrecognized role as a respiratory pathogen and resistance gene reservoir in cattle and has unknown zoonotic potential.
机译：AllibacteriumAtaatis是一种机会主义病原体，以前与家禽，家禽和偶尔人类死亡有关。我们获得的G.Anatis从支气管肺泡灌洗样品的10只小牛的灌洗样，带有支气管室无响应抗菌治疗。收集的分离物是多药抗性的，以抗耐药性，表现出5-7类抗微生物药物的抗性。全基因组测序揭示了24种不同的抗微生物抗性决定因素，包括前面未在腓铵属植物中描述的基因，例如Aada23，BLA Carb-8，Tet（Y）和QNRD1。一些抗性基因在抗性基因盒中紧密地连接，其中转座酶紧密接近或位于推定的移动元件或预测的质粒上。单核苷酸多态性基因分型揭示了G.Anatis分离株之间的大遗传变异，包括从同一农场检出的分离物。 G.Anatis可能在牛中呼吸病原体和抗性基因储存器发挥迄今为止的作用，并且具有未知的动物势。

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