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首页> 外文期刊>Journal of Behavioral and Brain Science >Characteristics and Mortality Risk Factors of Influenza-Associated Encephalopathy/Encephalitis in Children in a Tertiary Pediatric Hospital in China, 2016-2019
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Characteristics and Mortality Risk Factors of Influenza-Associated Encephalopathy/Encephalitis in Children in a Tertiary Pediatric Hospital in China, 2016-2019

机译：中国第三级儿科医院儿童流感相关脑病/脑炎的特征及死亡率风险因素，2016-2019

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Background: Seasonal influenza associated neurological complications had high mortality and morbidity rates in children. In this study, we aimed to investigate the clinical characteristics and mortality risk factors in children with influenza-associated encephalopathy. Methods: Retrospectively analyze the clinical data, laboratory tests, and imaging examinations of 68 children diagnosed with influenza-associated encephalopathy from January 2016 to December 2019 at Guangzhou Women and Children’s Medical Center, and the cases were divided into survival and non-survival groups by disease outcome and analyzed between two groups. Chi-square test or Mann-Whitney rank sum test was used for comparison between groups, and multivariate Logistic regression analysis was used for the analysis of risk factors for death. Results: Among the 68 children with influenza-associated encephalopathy, 40 were male, and 28 were female, aged from 3 months to 13 years, of which 66.18% (45/68) were under 5 years old. Pathogenetic tests showed that influenza virus type A accounted for 63.24% (43/68), and influenza virus type B accounted for 36.76% (25/68). Typical brain MRI changes in childhood influenza-associated encephalopathy were bilateral symmetrical lesions of the thalamus, basal ganglia, brainstem, and cerebellum. 68 patients had a mortality rate of 20.59% (14/68), with a significantly higher proportion of fever peak > 39°C, Acute Disturbance of Consciousness (ADOC), and cardiac arrest in the non-survival group than in the survival group (P < 0.05). Laboratory tests showed significantly higher in Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), Creatinine Kinase (CK), Lactate Dehydrogenase (LDH), lactate, and C-Reactive Protein (CRP). And CSF protein levels in the non-survival group compared with the survivor (P < 0.05), among them, elevated ALT, AST, LDH, and CSF protein were independent high-risk factors for death from influenza-associated encephalopathy. Conclusions: Children under 5 years of age with influenza are prone to combine neurological complications and have a higher mortality rate. Significant elevations in ALT, AST, LDH, and CSF proteins predict death from influenza-associated encephalopathy in children.
机译：背景：季节性流感相关的神经系统并发症具有高死亡率和儿童的发病率。在这项研究中，我们旨在探讨流感相关脑病儿童的临床特征和死亡率风险因素。 方法：回顾性分析2016年1月至2019年12月在广州妇女和儿童医疗中心诊断出患有流感相关脑病的68名儿童的临床资料，实验室测试和成像检查，并且该病例分为生存和非疾病结果生存群体并分析两组。 Chi-Square Test或Mann-Whitney Ranku和Rese用于组之间的比较，并且多变量逻辑回归分析用于分析死亡的风险因素。 结果：68例患有流感相关的脑病的儿童中，40名是男性，28例女性，从3个月到13岁，其中66.18％（45/68）未满5岁。致病性试验表明，流感病毒型占63.24％（43/68），B型甲型病毒型占36.76％（25/68）。儿童流感相关脑病的典型脑MRI变化是丘脑，基底神经节，脑干和小脑的双侧对称病变。 68例患者的死亡率为20.59％（14/68），具有明显高度的发热峰值> 39°C，意识急性扰动（ADOC），并在非生存组中的心脏骤停而不是生存组（P <0.05）。丙氨酸氨基转移酶（ALT），天冬氨酸转氨酶（AST），肌酐激酶（CK），乳酸脱氢酶（LDH），乳酸和C反应蛋白（CRP）中的实验室测试显着高。与幸存者（P <0.05）相比，非存活组中的CSF蛋白水平，其中升高，AST，LDH和CSF蛋白是从流感相关的脑病死亡的独立高危因素。 结论：5岁以下的流感患儿易患神经系统并发症并具有更高的死亡率。 ALT，AST，LDH和CSF蛋白质中显着升高预测儿童流感相关的脑病死亡。

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