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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Concordance of Bronchoalveolar Lavage Cytology with Transbronchial Lung Biopsies in Non-neoplastic Pulmonary Disease
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Concordance of Bronchoalveolar Lavage Cytology with Transbronchial Lung Biopsies in Non-neoplastic Pulmonary Disease

机译：支气管肺泡灌洗细胞学与跨肿瘤肺活量的非肿瘤性肺病的一致性

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In many pulmonary diseases, despite radiological & clinical investigations, laboratory tests and function studies, the diagnosis becomes difficult.Bronchoalveolar Lavage (BAL) is a minimally invasive method in which cells are collected from bronchial and alveolar spaces for cytology.This is facilitated by using a flexible bronchoscope with which a biopsy is taken following BAL.Bronchoscopy with BAL when used appropriately can offer correct diagnosis which in turn aids in proper management of the patient.Aim: To find the concordance of BAL findings with the histopathological features of Transbronchial Lung Biopsy (TBLB) in non-neoplastic lung diseases.Materials and Methods: It was a retrospective study conducted in Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka.A total of 40 patients presenting with clinicoradiological findings, suggesting a non-neoplastic lung disease in the year 2019, undergoing bronchoscopy with BAL and concurrent TBLB were chosen.The BAL fluid was processed and differential count of cells was done to classify according to the American Thoracic Society Guidelines.Concordance was checked between the diagnoses made on TBLB and BAL analysis.Results: In the present study, a total of 40 cases were included of which 13 (32.5%) cases showed neutrophilic, 16 (40%) cases showed lymphocytic, 5 (12.5%) cases showed eosinophilic and 6 (15%) cases showed normal cellular distribution on BAL cytology.Diagnoses on studying TBLB included nine cases of Nonspecific Interstitial Pneumonia, seven cases of Usual Interstitial Pneumonia, six cases of Bronchiolitis Obliterans Organising Pneumonia, three cases of Bronchiolitis, two cases each of pulmonary tuberculosis and granulomatous inflammation.There was one case each of actinomycosis, sarcoidosis, lung abscess and mucor mycosis.Normal histology was noted in seven cases.The sensitivity of BAL fluid analysis was found to be 84.84% and the concordance was 80%.The Kappa value obtained was 0.71 indicating good agreement/ concordance between BAL cytology and TBLB.Conclusion: The data from the current study suggest that differential cell counts in BAL provide diagnostic information of fundamental importance in frequently occurring non-neoplastic lung diseases in the community.
机译：在许多肺病中，尽管放射学和放射性疾病;临床调查，实验室测试和功能研究，诊断变得困难。腮腺炎血液灌洗（BAL）是一种微创方法，其中通过支气管和肺泡空间收集细胞以进行细胞学。通过使用活检的柔性支气管促进该细胞用BAL.BRONCHOCECHOPE使用BAL适当使用，可以提供正确的诊断，这反过来援助患者的适当管理。致颞瘤肺活检（TBLB）的组织病理学特征在非肿瘤肺中找到BAL结果的一致性疾病。材料和方法：这是在Kempegowda医学科学院，卡纳塔克卡州班加罗省医学科学研究所进行了一项回顾性研究，共有40例患有临床调查结果的患者，这表明2019年的非肿瘤肺病，遭受BAL和BAL和BAL和BAL和BAL）的非肿瘤肺病选择并发TBLB。加工BAL流体并对细胞的差异计数进行根据美国胸部社会的指南进行分类。在TBLB和BAL分析上诊断检查诊断。结果：在本研究中，包括40例患者，其中13例（32.5％）病例显示中性粒细胞，16（40 ％）患者显示淋巴细胞，5例（12.5％）病例显示嗜酸性嗜嗜酸性和6（15％）病例显示出对BAL细胞学的正常细胞分布。学习TBLB的含量包括9例非特异性间质性肺炎，7例通常间质肺炎病例，六种病例支气管炎梗死组织肺炎，三例支气管炎病例，两种患者肺结核和肉芽肿炎。在七种情况下注意到每种放线菌病，结节病，肺脓肿和粘膜菌霉菌。BAL流体的敏感性发现分析为84.84％，并且一致性为80％。获得的κ值为0.71，表明BAL细胞学之间的良好一致性/一致性TBLB.Clbclusion：来自目前的研究的数据表明，BAL中的差异细胞计数在社区中经常发生的非肿瘤肺病中的诊断信息。

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