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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Clinical and Microbiological Profile of Tracheal Aspirates in Chronic Kidney Disease Patients
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Clinical and Microbiological Profile of Tracheal Aspirates in Chronic Kidney Disease Patients

机译：慢性肾病患者气管吸出生物的临床和微生物概况

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Chronic Kidney Disease (CKD) is a chronic inflammatory state, which inturn suppresses the immune system.CKD patients are hence at more risk for nosocomial infections.Ventilator Associated Pneumonia (VAP) is one of the major nosocomial infections.If not treated early and appropriately, it increases hospital stay and expenses in turn increasing morbidity and mortality.In recent times, due to irrational and rampant use of antibiotics, there is an emergence of multidrug resistant strains of organisms which are difficult to treat.Aim: To study the clinical and microbiological profile of tracheal aspirate samples in CKD patients.Materials and Methods: It was a retrospective cross sectional study conducted in the renal Intensive Care Unit (ICU) of a Tertiary Care Centre, Institute of Nephrourology, Bengaluru over a period of two years from July 2018 to July 2020.Clinical and demographic data of patients who fulfilled the inclusion criteria was recorded.Tracheal aspirates were obtained by convenient sampling technique.The samples were cultured on Blood Agar (BA), chocolate agar, MacConkey agar and Sabouraud’s Dextrose Agar (SDA).Antibiotic sensitivity profiling was done by using Mueller Hinton agar.Statistical analysis was done using Statistical Package For The Social Sciences (SPSS) V23.0 software.Results: Sixty-nine samples were analysed over a period of two years.Males (66.66%) were in majority.Diabetes Mellitus (64%) was the most common associated risk factor.Among the total samples obtained, around 70% showed bacterial growth.Gram negative bacteria (92.4%) were the most commonly isolated microorganism.Among the Gram-negative bacteria, Acinetobacter baumanni (45.3%) was the most common followed by Klebsiella pneumoniae.Majority of the gram negative organisms were sensitive to Polymyxin B, colistin, tigecycline.Acinetobacter and Klebsiella showed resistance to 3rd generation cephalosporins, aminoglycosides and fluoroquinolones.Conclusion: There is emergence of extremely drug resistant gram negative organisms as the cause for VAP.They are dangerous and difficult to treat.They thus increase the hospital expenses by prolonging the hospital stay.Hence, the need of the hour is to formulate an appropriate antibiotic policy based on the population being treated and to follow strict infection control practices in ICU setup.
机译：慢性肾病（CKD）是一种慢性炎症状态，其意味着抑制免疫系统.CCD患者因此对医院感染的风险有更多的风险。血管相关肺炎（VAP）是主要的医院感染之一。如果未提前和适当治疗，它增加了医院的住宿和费用，反过来越来越多的发病率和死亡率。最近，由于抗生素的非理性和猖獗的使用，难以治疗的多药抗性株的出现。临床和研究临床和CKD患者气管抽吸样品的微生物概况。材料和方法：是在七月的两年内，孟加拉学院肾脏重症监护中心（ICU）在肾脏重症监护中心（ICU）中进行的回顾性横断面研究。 2018年至7月20日。记录了满足纳入标准的患者的临床和人口统计数据被记录。通过CONV获得了TRACHALALABLATES诱使样品在血液琼脂（BA）上培养样品，巧克力琼脂，麦克风琼脂和SDA）。通过使用Mueller Hinton琼脂进行antibiotic敏感性分析。使用统计包装为社会科学进行统计分析（SPSS）V23.0软件。结果：分析了69个样品，在两年内分析了大多数ales（66.66％）。二世均政部（64％）是最常见的相关风险因素。among总样品得到的，大约70％显示细菌生长。阴性细菌（92.4％）是最常见的微生物。革兰阴性细菌，肺菌（45.3％）是最常见的，其次是Klebsiella pneumoniae。克的克雷斯阴性生物体对多粘菌素B，山霉素，脱癸锌素。气球和Klebsiella敏感到第3代头孢菌素，氨基糖苷类和氟喹诺酮类的抗性。结论：极端的出现耐药革兰根阴性有机体作为VAP的原因。他们是危险的，难以治疗。因此，通过延长医院的住宿来增加医院费用。当时的需求是根据人口为基础制定适当的抗生素政策治疗和遵循ICU设置中严格的感染控制实践。

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