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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >The associations among RARRES2 rs17173608 gene polymorphism, serum chemerin, and non-traditional lipid profile in patients with metabolic syndrome
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The associations among RARRES2 rs17173608 gene polymorphism, serum chemerin, and non-traditional lipid profile in patients with metabolic syndrome

机译：RARRES2 RS17173608基因多态性，血清校长和代谢综合征患者的非传统脂质谱之间的关联

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Background:The adipokine chemerin retinoic acid receptor responder protein 2 (RARRES2) has been associated with insulin resistance, type II diabetes mellitus (T2DM), obesity, and metabolic syndrome (MetS). The impact of RARRES2 rs17173608 gene polymorphism on MetS and chemerin levels is not completely elucidated. This study included 100 patients with MetS and 68 healthy subjects (non-MetS group). The RARRES2 rs17173608 gene variant was analyzed by tetra amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR). Circulating chemerin levels were determined by ELISA. Serum urea, creatinine, fasting blood glucose, glycated hemoglobin, and traditional lipid profile were measured by colorimetric methods. The estimated glomerular filtration rate (eGFR) and non-traditional lipid parameters were calculated.ResultsSerum chemerin levels were significantly higher in MetS than in non-MetS subjects, type II diabetics (T2DM) than non-diabetics, and overweight compared to lean subjects, but it did not differ significantly between patients with and without hypertension. Strikingly, newly diagnosed diabetic patients had significantly higher serum chermerin levels. Correlation and multiple linear regression analysis showed that serum chemerin levels and non-traditional lipid parameters were correlated significantly with the clinical criteria of MetS. Genotyping and allelic frequency distribution of RARRES2 rs17173608 gene polymorphism showed its significant association with MetS. The TT genotype of RARRES2 rs17173608 SNP was more distributed in T2DM in comparison with non-diabetics, and it was associated significantly with higher serum chemerin and higher glycated hemoglobin levels. RARRES2 rs17173608 GG genotype and G allele frequency were less distributed in T2DM patients than in non-diabetic patients.ConclusionsThe RARRES2 rs17173608 SNP might have an impact on chemerin levels and lipid parameters. The GG genotype and G allele may have a protective role towards the risk of T2DM but not for MetS. Serum chemerin and non-traditional lipid profile are significantly associated with MetS.
机译：背景：Adipokine Chemerin视黄酸受体响应者蛋白2（ RARRES2 ）与胰岛素抗性有关，II型糖尿病（T2DM），肥胖症和代谢综合征（METS）。 RARRES2 RS17173608的影响不会完全阐明对METS和CHEMERIN水平的基因多态性。本研究包括100名Mets和68名健康受试者（非Mets组）。通过Tetra扩增耐火突变体系聚合酶链反应（T-Arms-PCR）分析了 RARRES2 RS17173608 基因变体。通过ELISA测定循环培养素水平。通过比色方法测量血清尿素，肌酐，空腹血糖，糖化血红蛋白和传统的脂质曲线。计算估计的肾小球过滤速率（EGFR）和非传统脂质参数。Mets的培养液水平明显高于非Mets受试者，II型糖尿病患者（T2DM）显着高于非糖尿病患者，而与精益受试者相比超重，但它在没有高血压的患者之间没有显着差异。令人惊讶的是，新诊断的糖尿病患者具有显着更高的血清Chermerin水平。相关性和多元线性回归分析表明，随着Mets的临床标准，显着与血清化学素水平和非传统脂质参数显着相关。基因分型和等位基因频率分布 RARRES2 RS17173608 基因多态性的基因多态性显示其与Mets的显着关系。与非糖尿病患者相比， RARRES2 RA17173608 SNP 的TT基因型更加分布在T2DM中，并且它与较高的血清化学蛋白和较高的糖化血红蛋白水平显着相关。 RARRES2 RS17173608 GG基因型和G等位基因频率小于T2DM患者的频率低于非糖尿病患者。Conclusionsthe RARRES2 RS17173608 rs17173608可能对Chemerin水平和脂质参数产生影响。 GG基因型和G等位基因可能对T2DM的风险具有保护作用，但不适用于满足。血清化学素和非传统脂质曲线与MET有显着相关。

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