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首页> 外文期刊>Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function >Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report
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Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report

机译：chemerin rs17173608和vaspin rs2236242基因多态性与代谢综合征之间的关联，初步报告

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摘要

Metabolic syndrome (MeS) is associated with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease. There is some evidence indicating that adipokines play a role in the development of MeS. The present study was aimed to investigate the impact of chemerin rs17173608 and vaspin rs2236242 gene polymorphisms with the risk of MeS in a sample of Iranian population.This case-control study was done on 151 subjects with MeS and 149 without MeS, as defined by NCEP-ATPIII. Tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) was designed to detect the polymorphisms. Our finding showed that there are significant differences in genotype frequencies between the groups regarding vaspin rs2236242 polymorphism (χ 2=18.74, p0.0001). A significant protection against MeS was found for vaspin rs2236242 in allele and genotypes (Odd Ratio [OR]=0.52; 95% confidence interval [CI]=0.37-0.72; p=0.0001, T vs A; OR=0.49; 95%CI=0.29-0.82; p=0.007, TT vs TA and OR=0.17; 95%CI=0.07-0.40; p0.0001, TT vs AA). Our finding showed positive association between chemerin rs17173608 polymorphism and risk of MeS (χ 2=7.70, p=0.021). The G allele increased the risk of MeS (OR=1.78; 95% CI=1.14-2.78; p=0.012) as compared to the T allele. In conclusion, our data suggest for the first time a significant association between vaspin rs2236242 and chemerin rs17173608 polymorphisms and the MeS in Zahedan, southeast Iran. Further studies with large sample size and different ethnicities are required to confirm our findings.
机译：代谢综合症（MeS）与2型糖尿病（T2DM）和心血管疾病的风险增加相关。有证据表明脂肪因子在MeS的发展中起作用。本研究旨在探讨chemerin rs17173608和vaspin rs2236242基因多态性对伊朗人群中MeS风险的影响。根据NCEP的定义，本病例对照研究针对151名MeS受试者和149名无MeS受试者进行。 -ATPIII。 Tetra扩增难治性突变系统-聚合酶链反应（T-ARMS-PCR）旨在检测多态性。我们的发现表明，关于vaspin rs2236242多态性，两组之间的基因型频率存在显着差异（χ2 = 18.74，p <0.0001）。在等位基因和基因型中发现了针对vaspin rs2236242的MeS的显着保护（奇数比[OR] = 0.52; 95％置信区间[CI] = 0.37-0.72; p = 0.0001，T对A; OR = 0.49; 95％CI = 0.29-0.82; p = 0.007，TT对TA和OR = 0.17; 95％CI = 0.07-0.40; p <0.0001，TT对AA）。我们的发现显示chemerin rs17173608基因多态性与MeS风险呈正相关（χ2 = 7.70，p = 0.021）。与T等位基因相比，G等位基因增加了发生MeS的风险（OR = 1.78; 95％CI = 1.14-2.78; p = 0.012）。总之，我们的数据首次表明vaspin rs2236242和chemerin rs17173608多态性与伊朗东南部Zahedan的MeS之间存在显着关联。需要进一步的大样本研究和不同种族的研究来证实我们的发现。

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