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首页> 外文期刊>Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland >Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens
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Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens

机译：用于治疗细菌病原体的金属基抗微生物化合物的评价

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Antimicrobial resistance (AMR) is one of the greatest global health challenges of modern times and its prevalence is rising worldwide. AMR within bacteria reduces the efficacy of antibiotics and increases both the morbidity and the mortality associated with bacterial infections. Despite this growing risk, few antibiotics with a novel mode of action are being produced, leading to a lack of antibiotics that can effectively treat bacterial infections with AMR. Metals have a history of antibacterial use but upon the discovery of antibiotics, often became overlooked as antibacterial agents. Meanwhile, metal-based complexes have been used as treatments for other diseases, such as the gold-containing drug auranofin, used to treat rheumatoid arthritis. Metal-based antibacterial compounds have novel modes of action that provide an advantage for the treatment of bacterial infections with resistance to conventional antibiotics. In this review, the antibacterial activity, mode of action, and potential for systemic use of a number of metal-based antibacterial complexes are discussed. The current limitations of these compounds are highlighted to determine if metal-based agents are a potential solution for the treatment of bacterial infections, especially those resistant to conventional antibiotics.
机译：抗微生物抗性（AMR）是近代最大的全球健康挑战之一，其普遍存在的普遍存在世界范围内。细菌内的AMR降低了抗生素的疗效，并增加了与细菌感染相关的发病率和死亡率。尽管风险不及劲，但少量具有新的行动模式的抗生素，导致缺乏可以有效治疗患有AMR的细菌感染的抗生素。金属具有抗菌用途的历史，但在发现抗生素时，通常被忽略被视为抗菌剂。同时，金属基配合物已被用作其他疾病的治疗，例如含金的药物氧橡胶，用于治疗类风湿性关节炎。基于金属的抗菌化合物具有新的作用方式，提供了治疗具有抗常规抗生素的细菌感染的优势。在本次综述中，讨论了抗菌活性，动作模式和系统使用许多金属基抗菌复合物的潜力。突出显示这些化合物的当前限制以确定金属的试剂是治疗细菌感染的潜在溶液，尤其是耐常规抗生素的潜在溶液。

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