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首页> 外文期刊>Advances in Rheumatology >Risk factors for the flare of systemic lupus erythematosus and its influence on prognosis: a single-center retrospective analysis
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Risk factors for the flare of systemic lupus erythematosus and its influence on prognosis: a single-center retrospective analysis

机译：Systemic Lupus红斑发芽的危险因素及其对预后的影响：单中心回顾性分析

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To explore the risk factors for systemic lupus erythematosus (SLE) flare and their impact on prognosis. The clinical characteristics, laboratory results, and treatment plans of 121 patients with SLE flare were retrospectively analyzed. Ninety-eight SLE outpatients with sustained remission during the same period were selected as controls. Logistic multivariate regression analysis was employed to screen for risk factors for SLE flare. Infection, thrombocytopenia, arthritis, anti-nucleosome antibodies positive, anti-β2-glycoprotein I (IgG) antibodies positive, and patient’s self-discontinuation of medicine maintenance therapy might be risk factors for SLE flare. Patients who discontinued medicine maintenance therapy by themselves had a significantly higher rate of severe SLE flare than patients with regular medicine maintenance therapy (P?=?0.033). The incidence of anemia associated with SLE (P?=?0.001), serositis (P?=?0.005), and pulmonary hypertension (P?=?0.003) in patients who discontinued medicine maintenance therapy were significantly higher than patients with regular medicine maintenance therapy. SLE patients with regular medicine maintenance therapy for less than 3?years had a higher risk of pulmonary hypertension than those with regular medicine maintenance therapy longer than 3?years (P?=?0.034). The accompanying thrombocytopenia, arthritis, anti-nucleosome antibodies positive and anti-β2-glycoprotein I (IgG) antibodies positive at the onset of SLE may affect the prognosis of SLE. Patient’s self-discontinuation of medicine maintenance therapy is the main cause of SLE flare, which may induce severe flare in SLE patients and lead to a significantly higher incidence of pulmonary hypertension.
机译：探讨全身狼疮红斑（SLE）火炬的危险因素及其对预后的影响。回顾性分析了121例SLE耀斑患者的临床特征，实验室结果和治疗计划。选择在同一时期持续缓解的九十八个SLE门诊为对照。物流多变量回归分析用于筛选SLE Flare的危险因素。感染，血小板减少症，关节炎，抗核小体抗体阳性，抗β2-糖蛋白I（IgG）抗体阳性，患者的自我停止药物维持治疗可能是SLE Flare的危险因素。由于常规药物维持治疗的患者，患有药物维持治疗的患者的严重SLE火光率明显较高（P？= 0.033）。与SLE（p？= 0.001）相关的贫血血症的发病率（p？= 0.005）和肺动脉高压（p？= 0.003），患有药物维持治疗的患者显着高于常规医学维护的患者治疗。 SLE常规药物维持治疗患者少于3岁以下的肺动脉高压风险较高，患有常规药物维持治疗的风险较高，而不是3？年（P？= 0.034）。伴随血小板减少症，关节炎，抗核体抗体阳性和抗β2-糖蛋白I（IgG）抗体在SLE发作时阳性阳性阳性阳性可能影响SLE的预后。患者的自我停止药物维持疗法是SLE Flare的主要原因，可在SLE患者中诱导严重爆发，并导致肺动脉高压发病率显着。

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