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首页> 外文期刊>Journal of International Medical Research >Effect of bioimpedance-defined overhydration parameters on mortality and cardiovascular events in patients undergoing dialysis: a systematic review and meta-analysis
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Effect of bioimpedance-defined overhydration parameters on mortality and cardiovascular events in patients undergoing dialysis: a systematic review and meta-analysis

机译:生物阻抗定义过水合参数对透析患者死亡率和心血管事件的影响:系统审查和荟萃分析

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Objective To evaluate the role of bioimpedance-defined overhydration (BI-OH) parameters in predicting the risk of mortality and cardiovascular (CV) events in patients undergoing dialysis. Methods We searched multiple electronic databases for studies investigating BI-OH indicators in the prediction of mortality and CV events through 23 May 2020. We assessed the effect of BI-OH indexes using unadjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Sensitivity analysis was used for each outcome. Results We included 55 studies with 104,758 patients in the meta-analysis. Extracellular water/total body water (ECW/TBW)?&0.4 (HR 5.912, 95% CI: 2.016–17.342), ECW/intracellular water (ICW) for every 0.01 increase (HR 1.041, 95% CI: 1.031–1.051), and OH/ECW?&15% (HR 2.722, 95% CI: 2.005–3.439) increased the risk of mortality in patients receiving dialysis. ECW/TBW?&0.4 (HR 2.679, 95% CI: 1.345–5.339) and ECW/ICW per increment of 10% (HR 1.032, 95% CI: 1.017–1.047) were associated with an increased risk of CV events in patients undergoing dialysis. A 1-degree increase in phase angle was a protective factor for both mortality (HR 0.676, 95% CI: 0.474–0.879) and CV events (HR 0.736, 95% CI: 0.589–0.920). Conclusions BI-OH parameters might be independent predictors for mortality and CV events in patients undergoing dialysis.
机译:目的评价生物阻抗定义的过水(Bi-OH)参数在预测透析患者中​​预测死亡率和心血管(CV)事件的风险。方法我们搜索了多个电子数据库,用于研究预测死亡率和CV事件中的二孔指标的研究通过2020年5月23日。我们评估了使用不调整的危险比(HRS)和95%置信区间(CIS)的Bi-OH指标的影响。每个结果使用敏感性分析。结果我们在Meta分析中包括55项患者的55项患者。细胞外水/全身水(ECW / TBW)?& 0.4(HR 5.912,95%CI:2.016-17.342),ECW /细胞内水(ICW)增加每0.01(HR 1.041,95%CI:1.031 -1.051)和OH / ECW?& GT; 15%(HR 2.722,95%CI:2.005-3.439)增加接受透析患者的死亡率。 ECW / TBW?& 0.4(HR 2.679,95%CI:1.345-5.339)和每个增量的ECW / ICW为10%(HR 1.032,95%CI:1.017-1.047)与CV的风险增加有关透析患者的事件。相位角的1度增加是死亡率的保护因子(HR 0.676,95%CI:0.474-0.879)和CV事件(HR 0.736,95%CI:0.589-0.920)。结论Bi-OH参数可能是透析患者死亡率和CV事件的独立预测因子。

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