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首页> 外文期刊>PLoS One >Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients
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Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients

机译：中枢线相关医院血液流血感染血液学和肿瘤患者的发病率，危险因素和医疗成本

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摘要

Non-implanted central vascular catheters (CVC) are frequently required for therapy in hospitalized patients with hematological malignancies or solid tumors. However, CVCs may represent a source for bloodstream infections (central line-associated bloodstream infections, CLABSI) and, thus, may increase morbidity and mortality of these patients. A retrospective cohort study over 3 years was performed. Risk factors were determined and evaluated by a multivariable logistic regression analysis. Healthcare costs of CLABSI were analyzed in a matched case-control study. In total 610 patients got included with a CLABSI incidence of 10.6 cases per 1,000 CVC days. The use of more than one CVC per case, CVC insertion for conditioning for stem cell transplantation, acute myeloid leukemia, leukocytopenia (≤ 1000/μL), carbapenem therapy and pulmonary diseases were independent risk factors for CLABSI. Hospital costs directly attributed to the onset of CLABSI were 8,810 € per case. CLABSI had a significant impact on the overall healthcare costs. Knowledge about risk factors and infection control measures for CLABSI prevention is crucial for best clinical practice.
机译：在血液天动病学恶性肿瘤或实体肿瘤的住院患者中，通常需要非植入的中央血管导管（CVC）。然而，CVC可以代表血流感染的源（中央线相关的血流感染，clabsi），因此可能会增加这些患者的发病率和死亡率。追溯队列在3年超过3年的研究。通过多变量的逻辑回归分析确定和评估危险因素。在匹配的案例对照研究中分析了Clabsi的医疗费用。总共610例患者随附Clabsi发病率为每1000个CVC天10.6例。使用多个CVC每个案例，CVC插入用于干细胞移植的调节，急性髓性白血病，白细胞减少症（≤1000/μl），鲤鱼治疗和肺部疾病是Clabsi的独立危险因素。医院成本直接归因于Clabsi发作的8,810欧元。 Clabsi对整体医疗保健成本产生了重大影响。关于Clabsi预防危险因素和感染控制措施的知识对于最佳临床实践至关重要。

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