• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer Communications >Aspirin-based chemoprevention of colorectal cancer: The role for gut microbiota
【24h】

Aspirin-based chemoprevention of colorectal cancer: The role for gut microbiota

机译：基于阿司匹林的结直肠癌化学预防：肠道微生物肿瘤的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Despite improvements in the surveillance, diagnosis, and multimodal therapies for colorectal cancer (CRC), its mortality is persistently high worldwide [1-3]. Continuing efforts for controlling CRC using similar strategies seems not sufficient given the persistent threats of CRC on human health. Prevention, in the form of chemoprevention, may provide another cost-effective way to enhance the outcomes of individuals at risk of developing CRC. In this regard, aspirin is emerging as a promising agent in the chemoprevention of CRC, especially for those at risk of cardiovascular diseases. However, the overall efficacy (～30%) reported from multiple randomized controlled trials is still limited [4-6]. The reasons for the limited efficacies of aspirin are elusive. Genetic and epigenetic factors are thought to be critical in relation to drug responses [7, 8]. Cyclooxygenase-2 (COX-2) has been identified as one of the important factors affecting aspirin response. In one study by Chan et al. [9], the authors demonstrated that aspirin could reduce the risk of CRC in individuals that overexpressed COX-2 but not in those with a weak or absent expression of COX-2. The percentage of COX-2 overexpression in that study was 67%, much higher than the observed responsive rate in clinical trials [9]; suggesting that the status of COX-2 expression cannot fully explain the responsiveness to aspirin-based chemoprevention. Other factors associated with the chemopreventive efficacy of aspirin are still needed to be explored and elucidated.
机译：尽管对直肠癌（CRC）的监测，诊断和多式联运疗法有所改善，但其死亡率在全球范围内持续高位[1-3]。考虑到CRC对人类健康的持续威胁，继续努力控制CRC的持续努力。以化学预防的形式预防可以提供另一种成本有效的方法来增强患CRC的风险的个体的结果。在这方面，阿司匹林在CRC的化学灌注中被出现为有希望的试剂，特别是对于那些有心血管疾病风险的人。然而，从多次随机对照试验报告的总疗效（〜30％）仍然有限[4-6]。阿司匹林有限效率的原因是难以捉摸的。遗传和表观遗传因素被认为与药物反应有关[7,8]是至关重要的。环氧氧酶-2（COX-2）已被鉴定为影响阿司匹林反应的重要因素之一。在一项研究中，Chan等人。 [9]，作者证明阿司匹林可以降低过表达COX-2的个体中CRC的风险，但不含COX-2的弱或缺乏表达的人。该研究的Cox-2过表达的百分比为67％，远高于临床试验中观察到的响应速率[9];表明COX-2表达的状态不能完全解释基于阿司匹林的化学预防的反应性。仍然需要探索与阿司匹林的化学预防效果相关的其他因素才能探索和阐明。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号