...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Carcinogenesis >Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation
【24h】

Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation

机译：通过黑覆盆子花青素的结直肠癌化学预防涉及肠道微生物肿瘤和SFRP2去甲基化的调节

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Freeze-dried black raspberry (BRB) powder is considered as a potential cancer chemopreventive agent. In this study, we fed azoxymethane (AOM)/dextran sodium sulfate (DSS)-treated C57BL/6J mice with a diet containing BRB anthocyanins for 12 weeks, and this led to a reduction in colon carcinogenesis. These animals had consistently lower tumor multiplicity compared with AOM/DSS-treated mice not receiving BRB anthocyanins. In AOM/DSS-treated mice, the number of pathogenic bacteria, including Desulfovibrio sp. and Enterococcus spp., was increased significantly, whereas probiotics such as Eubacterium rectale, Faecalibacterium prausnitzii and Lactobacillus were dramatically decreased, but BRB anthocyanins supplement could reverse this imbalance in gut microbiota. BRB anthocyanins also caused the demethylation of the SFRP2 gene promoter, resulting in increased expression of SFRP2, both at the mRNA and protein levels. Furthermore, the expression levels of DNMT31 and DNMT3B, as well as of p-STAT3 were downregulated by BRB anthocyanins in these animals. Taken together, these results suggested that BRB anthocyanins could modulate the composition of gut commensal microbiota, and changes in inflammation and the methylation status of the SFRP2 gene may play a central role in the chemoprevention of CRC.
机译：冷冻干燥的黑覆盆子（BRB）粉末被认为是潜在的癌症化学预防剂。在这项研究中，我们将含氮氧基甲烷（AOM）/葡聚糖硫酸钠（DSS） - 处理的C57BL / 6J小鼠用含有BRB花青素12周的饮食，并且这导致结肠癌的降低。与未接受BRB花青素的AOM / DSS处理的小鼠相比，这些动物始终如一的肿瘤多重性。在AOM / DSS处理的小鼠中，病原细菌的数量，包括脱硫纤维纤维。和肠球菌SPP。，较明显增加，而益生菌如异级，Proausnitzii和乳酸杆菌，但BRB花青素补充剂可以逆转肠道微生物的这种不平衡。 BRB花青素还引起了SFRP2基因启动子的去甲基化，导致在mRNA和蛋白质水平上增加了SFRP2的表达。此外，DNMT31和DNMT3B以及P-STAT3的表达水平通过这些动物的BRB花青素下调。总之，这些结果表明，BRB花青素可以调节肠道非团体的组成，并且SFRP2基因的炎症和甲基化状态可能在CRC的化学预防中起着核心作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号