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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Biogenesis of copper nanoparticles (Cu-NPs) using leaf extract of Allium noeanum , antioxidant and in-vitro cytotoxicity
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Biogenesis of copper nanoparticles (Cu-NPs) using leaf extract of Allium noeanum , antioxidant and in-vitro cytotoxicity

机译：使用葱属，抗氧化剂和体外细胞毒性的叶提取物的铜纳米粒子（Cu-NPS）生物发生

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In this research, we formulated new chemotherapeutic copper nanoparticles (Cu NPs) containing Allium noeanum Reut. ex Regel leaf for treating human endometrial cancer. For investigating the antioxidant activitiy, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test was used. MTT test was used on normal (Human umbilical vein endothelial cells (HUVECs)) and human endometrial cancer (Ishikawa, HEC-1-A, HEC-1-B, and KLE) cell lines for comparing the anti-human endometrial cancer properties of Cu(NO 3 ) 2 , A. noeanum leaf aqueous extract, and copper nanoparticles. Copper nanoparticles had high cell death and anti-human endometrial cancer effects against Ishikawa, HEC-1-A, HEC-1-B, and KLE cell lines. The IC50 of A. noeanum leaf aqueous extract and copper nanoparticles against HEC-1-B cell line were 548 and 331?μg/mL, respectively; against HEC-1-A cell line were 583 and 356?μg/mL, respectively; against KLE cell line were 609 and 411?μg/mL, respectively; and against Ishikawa cell line were 560 and 357?μg/mL, respectively. Among the above cell lines, the best result of anti-human endometrial cancer properties of copper nanoparticles was gained in the cell line of HEC-1-B. This study indicated excellent anti-human endometrial cancer potentials of copper nanoparticles containing A. noeanum in the in vitro condition.
机译：在这项研究中，我们制定了含有葱属Noeanum Reut的新化学治疗铜纳米粒子（Cu NPS）。 EX Regel叶治疗人子宫内膜癌。为了研究抗氧化活性，使用2,2-二苯基-1-富铬酰基（DPPH）试验。 MTT试验用于正常（人脐静脉内皮细胞（HUVECS））和人子宫内膜癌（Ishikawa，HEC-1-A，HEC-1-B和KLE）细胞系，用于比较抗人类子宫内膜癌症特性Cu（No 3）2，A. noeanum叶水质提取物和铜纳米颗粒。铜纳米粒子具有高细胞死亡和抗人类子宫内膜癌症的影响，对抗Ishikawa，HEC-1-A，HEC-1-B和Kle细胞系。 A. noeanum叶片水提取物和针对HEC-1-B细胞系的铜纳米颗粒的IC 50分别为548和331Ω×ml;对抗HEC-1-A细胞系分别为583和356ΩΩ×μg/ ml;对kle细胞系分别为609和411Ωμg/ ml;并反对石川细胞系分别为560和357ΩΩ×ml。在上述细胞系中，在HEC-1-B的细胞系中获得了铜纳米颗粒的抗人类子宫内膜特性的最佳结果。本研究表明，在体外条件下含有A. noeanum的铜纳米颗粒的优异的抗人类子宫内膜癌电位。

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