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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Nanodelivery of triamcinolone acetonide with PLGA-chitosan nanoparticles for the treatment of ocular inflammation
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Nanodelivery of triamcinolone acetonide with PLGA-chitosan nanoparticles for the treatment of ocular inflammation

机译：抗钙氨基酮乙酰纳米酮与PLGA-壳聚糖纳米粒子治疗眼部炎症

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Triamcinolone acetonide (TA) is widely indicated in the treatment of several ocular disorders, but the free drug suspension limits its clinical benefits and commercial compositions cause adverse ocular effects. In this study, TA was formulated in poly( d , l -lactide-co-glycolide) (PLGA)-chitosan (PLC) nanoparticles (NPs) for the treatment of ocular inflammatory diseases. TA-loaded PLC NPs exhibited excellent anti-inflammatory activity against human corneal epithelial (HCE) cells and significantly reduced the secretion of interleukin (IL)-6 in tumour necrosis factor (TNF)-α activated cells. In a rabbit model, TA-loaded PLC NPs did not show any typical clinical signs of eye inflammation and significantly alleviated inflammatory signs, compared with free TA suspension, at 24?h after a single dose. TA-loaded PLC NPs exhibited a greater aqueous humour transparency (%AHT), compared with that of normal saline (NS) or free TA suspension, indicating reduction in anterior chamber fogginess. Pharmacokinetic analysis of rabbit eyes revealed that TA-loaded PLC NPs peaked at 6?h. Substantial concentrations of TA were observed until 24?h, indicating the superiority of this PLC-based nanocarrier system. Overall, PLC-based NP formulations offer a new approach for the treatment of ocular inflammatory diseases.
机译：抗菊酮酮丙酮酮（TA）在治疗几种眼镜疾病中被广泛表明，但自由药物悬浮液限制其临床益处和商业组合物导致不良眼镜效应。在该研究中，在聚（D，L-氯化物 - 共乙酰化）（PLGA）-CHITOSAN（PLC）纳米颗粒（NPS）中配制TA，用于治疗眼部炎性疾病。 TA-Loaded PLC NPS表现出对人角膜上皮（HCE）细胞的优异的抗炎活动，并显着降低了肿瘤坏死因子（TNF）-α活化细胞中白细胞介素（IL）-6的分泌。在兔模型中，与单剂量后24μm相比，TA加载的PLC NP没有显示出眼睛炎症的任何典型临床症状和显着缓解的炎症症状。加载的PLC NPS表现出更大的液体透明度（％AHT），与正常盐水（NS）或游离TA悬浮液相比，表明前房雾气减少。兔眼的药代动力学分析显示，TA负载的PLC NPS在6ΩH峰值上达到峰值。观察到大量浓度的TA直到24μm，表示该PLC基纳米载波系统的优越性。总体而言，基于PLC的NP配方提供了一种治疗眼炎疾病的新方法。

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