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Risk Factors and Incidence of Acute Ischemic Stroke: A Comparative Study Between Young Adults and Older Adults

机译:急性缺血性脑卒中的危险因素和发病率:年轻成人和老年人的比较研究

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Introduction Approximately 5-10% of strokes occur in adults of less than 45 years of age. The rising prevalence of stroke risk factors may increase stroke rates in young adults (YA). We aimed to compare risk factors and outcomes of acute ischemic stroke (AIS) among YA. Methods Adult hospitalizations for AIS and concurrent risk factors were found in the Nationwide Inpatient Sample database. Weighted analysis using chi-square and multivariable survey logistic regression was performed to evaluate AIS-related outcomes and risk factors among?YA (18-45 years) and older patients. Results A total of 4,224,924 AIS hospitalizations were identified from?2003 to 2014, out of which 198,378 (4.7%) were YA. Prevalence trend of YA with AIS showed incremental pattern over time (2003: 4.36% to 2014: 4.7%;?pTrend0.0001). In regression analysis, the risk factors associated with AIS in YA were obesity (adjusted odds ratio {aOR}: 2.26; p0.0001), drug abuse (aOR: 2.56; p0.0001), history of smoking (aOR: 1.20; p0.0001), infective endocarditis (aOR: 2.08; p0.0001), cardiomyopathy (aOR: 2.11; p0.0001), rheumatic fever (aOR: 4.27; p=0.0014), atrial septal disease (aOR: 2.46; p0.0001), ventricular septal disease (aOR: 4.99; p0.0001), HIV infection (aOR: 4.36; p0.0001), brain tumors (aOR: 7.89; p0.0001), epilepsy (aOR: 1.43; p0.0001), end stage renal disease (aOR: 2.19; p0.0001), systemic lupus erythematous (aOR: 3.76; p0.0001), polymyositis (aOR: 2.72; p=0.0105), ankylosis spondylosis (aOR: 2.42; p=0.0082), hypercoagulable state (aOR: 4.03; p0.0001), polyarteritis nodosa (aOR: 5.65; p=0.0004), and fibromuscular dysplasia (aOR: 2.83; p0.0001). Conclusion There is an increasing trend in AIS prevalence over time among YA. Both traditional and non-traditional risk factors suggest that greater awareness is needed, with prevention strategies for AIS among young adults.
机译:引言大约5-10%的中风发生在不到45岁的成年人中。卒中危险因素的普遍性可能会增加年轻成年人(YA)的中风率。我们旨在比较YA中急性缺血性卒中(AIS)的风险因素和结果。方法在全国住院样本数据库中发现了AIS和并发危险因素的成人住院。使用Chi-Square和多变量测量逻辑回归进行加权分析,以评估AIS相关的结果和危险因素?YA(18-45岁)和老年患者。结果共有4,224,924名AIS住院治疗2003年至2014年,其中198,378(4.7%)是YA。随着时间的推移,AIS的患病率为YA显示增量模式(2003:4.36%至2014:4.7%;波动& 0.0001)。在回归分析中,与YA中的AIS相关的风险因素是肥胖症(调整的赔率比{AOR}:2.26; P <0.0001),吸毒历史(AOR:1.20; P&LT; ; 0.0001),感染性心内膜炎(AOR:2.08; P <0.0001),心肌病(AOR:2.11; P <0.0001),风湿热(AOR:4.27; P = 0.0014),间隔疾病(AOR:2.46; P <0.01 ),心室间隔疾病(AOR:4.99; p& 0.0001),HIV感染(AOR:4.36; p& 0.0001),脑肿瘤(aor:7.89; p <0.0001),癫痫(aor:1.43; p& 0.0001),结束阶段肾病(AOR:2.19; P <0.0001),全身狼疮红斑(AOR:3.76; P <0.0001),Polymyositis(AOR:2.72; P = 0.0105),Ankylosis Spondylosis(AOR:2.42; P = 0.0082),高可凝固状态(AOR:4.03; P <0.0001),聚调节炎(AOR:5.65; p = 0.0004),和纤维瘤发育不良(AOR:2.83; P <0.0001)。结论YA间随着时间的推移存在越来越多的趋势。传统和非传统风险因素都表明,需要更大的意识,在年轻人中的AIS预防策略。

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