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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Risk factors associated with retinopathy in young people with type 1 diabetes in Bangladesh
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Risk factors associated with retinopathy in young people with type 1 diabetes in Bangladesh

机译：孟加拉国1型糖尿病患者的患者视网膜病变相关的危险因素

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Objectives Diabetic retinopathy (DR) is the most common microvascular complications seen in children and adolescents with type 1 diabetes. The aim of this study was to evaluate the prevalence of retinopathy and its association with other risk factors in young people with type 1 diabetes. Methods This study was a cross‐sectional study, which was done as part of the ongoing complication assessment in the paediatric diabetes clinic in BIRDEM (Bangladesh Institute of Research and Rehabilitation of Diabetes Endocrine and Metabolic Disorders), a tertiary care hospital. Children, adolescents and young adults with type 1 diabetes who were having diabetes duration 2?years were included in this study. Retinopathy was detected using fundal photography, and grading was done by National Screening Committee of UK by trained ophthalmologists. Results Diabetic retinopathy was observed in 44 (6.6%) patients. Majority (95.4%) of them had early diabetic retinopathy in the form of mild NPDR (nonproliferative diabetic retinopathy) (R1). Patients with retinopathy had higher HbA1c 9.6[8.4‐12.3] vs 9.1 [7.9‐10.8] ( P = .013), longer duration of diabetes 7.6 [5.5‐10.7] vs 6.0 [4.5‐8.2] years ( P =?.001) and were older 21.5 [18.0‐23.0] vs 18 [16.0‐21.0] years ( P =?.0001) compared with those without retinopathy. On multivariate regression analysis, higher age and median HbA1c were significantly associated with DR. Conclusions Higher HbA1c was the only modifiable risk factor for development of DR in our study population. Early detection of DR with improvement of glycaemic control may reduce the risk of progression of severe stages of the disease.
机译：目的患糖尿病视网膜病变（DR）是儿童和青少年中最常见的微血管并发症，具有1型糖尿病。本研究的目的是评估视网膜病变的患病率及其与1型糖尿病型患者的其他危险因素的关系。方法本研究是一项横截面研究，作为Birdem儿科糖尿病诊所的正在进行的并发症评估的一部分（孟加拉国的研究和糖尿病内分泌和代谢紊乱，糖尿病内分泌和代谢紊乱研究所）的一部分。儿童，青少年和年轻人有1型糖尿病的糖尿病患者持续时间＆ 2？岁月纳入这项研究。使用基石摄影检测到视网膜病变，并通过训练有素的眼科医生国家筛查委员会进行评分。结果在44名（6.6％）患者中观察到糖尿病视网膜病变。其中大多数（95.4％）他们的早期糖尿病视网膜病变为轻度NPDR（非抗生素糖尿病视网膜病变）（R1）。视网膜病变患者具有较高的HBA1C 9.6 [8.4-12.3] Vs 9.1 [7.9-10.8]（p = .013），糖尿病持续时间较长7.6 [5.5-10.7] VS 6.0 [4.5-8.2]年（P = 001 ）和21.5岁[18.0-23.0] vs 18 [16.0-21.0]年（p = _ 0001）与那些没有视网膜病变的人相比。在多元回归分析中，高龄和中位数HBA1C与DR显着相关。结论HBA1C更高的HBA1C是我们学习人口博士开发的唯一可修改的危险因素。早期检测糖类术治疗的改善可能会降低疾病严重阶段进展的风险。

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