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Differences in quality of life between genders in acromegaly

机译：烦恼者之间的生活质量差异

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Objective To study the impact of secondary mental disorders in patients affected with acromegaly and correlate them with quality of life (QoL) and disease status. Design An observational transversal descriptive and comparative study that evaluates QoL's impact due to secondary mental disorders in affected Mexicans with acromegaly using AcroQoL and SF-36 instruments. Correlation of the results with the disease's biochemical status was performed. According to Beck's scales, anxiety and depression analyses evaluate QoL's impact, and its gender variability is described. Results Eighty-five patients with diagnoses of acromegaly were included. The mean age was 43.18?years, 47 being women (55.29%). The mean age at diagnosis was 37.95?years, with no difference between men and women. AcroQoL and SF-36 global and sub-domain scores differed significantly between men and women, the latter having lower global and individual sub-domain scores. The mean score of QoL, according to AcroQoL, is 59.40. In women, the mean values are less (55.13) than men (64.68), p =?0.021. The sub-domain analyses’ scores in physical, appearance and social relationships were less in women (53.21; 47.34; 62.32) than men (62.68; 56.76; 73.87) p =?0.044, 0.069 and 0.013, respectively. Higher Beck's Depression Inventory (BDI) and Beck's Anxiety Inventory (BAI) scores correlated with lower QoL as assessed by global and individual sub-domain scores. Women presented significantly higher BDI and BAI mean scores when compared to men regardless of their biochemical status. Anxiety ( p =?0.027) and depression ( p ?0.001) severity were higher in women compared to men. Conclusion Correlations between female gender, depression/anxiety scores and QoL require further validation. There is much to be routinely done to improve secondary psychopathology in patients affected by this disease. The need for mental status screening at diagnosis should be emphasized to identify secondary mental illnesses to improve QoL with its treatment.
机译：目的探讨患有痛苦患者的继发性精神障碍的影响，将它们与生活质量（QOL）和疾病状况相关联。设计一种观察横向描述性和比较研究，这些描述和比较研究，这些比较研究由于使用ACROQOL和SF-36仪器的患者受影响的墨西哥人的继发性墨西哥人的影响。进行了疾病的生化状态的结果的相关性。根据Beck的尺度，焦虑和抑郁分析评估QOL的影响，描述了其性别变异性。结果包括85例诊断临床诊断患者。平均年龄是43.18年的年龄，47年是女性（55.29％）。诊断的平均年龄为37.95年，男女之间没有区别。 Acroqol和SF-36全球和子域名分数在男女和女性之间有显着不同，后者具有较低的全局和各个子域分数。 acroqol的说法，QoL的平均得分为59.40。在女性中，平均值比男性更少（55.13）（64.68），P = 0.021。女性（53.21; 47.34; 62.32）的身体，外观和社会关系中的子域分析的分数比男性更少（62.68; 56.76; 73.87）P = 0.044,0.069和0.013。较高的Beck的抑郁库存（BDI）和Beck的焦虑库存（BIAI）与全球和个人子域分数评估的QoL相关的分数相关。与男性相比，妇女在与男性相比，均明显高于BDI和白的分数，无论其生化状态如何。与男性相比，女性的焦虑（P = 0.027）和抑郁症（P＆ 0.001）严重程度较高。结论女性性别，抑郁/焦虑评分与QOL之间的相关性需要进一步验证。有很多常规的措施来改善受该疾病影响的患者的二次精神病理学。应强调对诊断进行精神状态筛查的需求，以确定继发性精神疾病，以改善QOL及其治疗。

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