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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >The rapid effects of sleeve gastrectomy on glucose homeostasis and resolution of diabetes mellitus
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The rapid effects of sleeve gastrectomy on glucose homeostasis and resolution of diabetes mellitus

机译：袖子胃切除对葡萄糖稳态和糖尿病分辨率的快速影响

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Aims Type 2 diabetes caused by obesity is increasing globally. Bariatric surgical procedures are known to have positive effects on glucose homeostasis through neurohormonal action mechanisms. In the present study, we aimed to investigate the factors influencing glucose homeostasis independent of weight loss after the laparoscopic sleeve gastrectomy (LSG). Methods Patients who underwent LSG for morbid obesity in a 3‐year period were evaluated. Data on demographics, clinical characteristics (duration of diabetes, resected gastric volume, antral resection margin) and laboratory parameters (preoperative and postoperative blood glucose on fasting, preoperative HbA1c levels and first‐year HbA1c levels) were retrospectively reviewed. Effect of patients' body mass index (50?kg/m 2 , ≥50?kg/m 2 ), first‐year excess weight loss (EWL%) rates, age (≥50?years, 50?years), duration of diabetes (≥5?years, 5?years) and antral resection margin (≥3?cm, 3?cm) on postoperative blood glucose profile and diabetic resolution status were investigated. Results Total of 61 patients constituted the study group. There were 40 female and 21 male patients with an average age of 43.8?±?10.5?years (19‐67?years). Preoperatively, mean BMI, blood glucose levels and HbA1c were?48.8?±?8.5?kg/m 2 , 133.6?±?47.4?mg/dL and 7.4?±?1.1, respectively. The mean blood glucose level at the postoperatively 5th day was 88.0?±?16.3?mg/dL (median: 84?mg/dL) ( P ?.001). Fifty‐nine out of 61 patients improved their glycaemic control. Conclusions It is noteworthy that LSG can control blood glucose levels in short term after surgery regardless of weight loss.?Therefore, LSG should be preferred at earlier stages in the treatment of obesity‐related T2DM in order to prevent T2DM‐related complications.
机译：AIMS由肥胖造成的2型糖尿病在全球范围内增加。众所周知，野生外科手术程序通过神经内部作用机制对葡萄糖稳态产生积极影响。在本研究中，我们旨在探讨影响腹腔镜套管胃切除术（LSG）后的体重减轻术的因素。方法评估了在3年期间接受病态肥胖的患者的患者进行了评估。回顾性审查了关于人口统计学的数据，临床特征（糖尿病持续时间，切除胃部，胃肠术术前和术前和术前和血糖，术前，HBA1C水平和第一年HBA1C水平）。患者体重指数的影响（＆ 50？kg / m 2，≥50Ωkg / m 2），一年过量减肥（Ewl％）率，年龄（≥50岁，＆lt 5 50？ ），糖尿病持续时间（≥5？岁，5年）和术后血糖型和糖尿病分辨率状态的嗜睡缘（≥3Ωcm，≥3Ωcm）。结果61名患者共有61名患者。有40名女性和21名男性患者，平均年龄为43.8？±10.5？年（19-67岁？年）。术前，平均BMI，血糖水平和HBA1c分别为α48.8？±8.5Ω·kg / m 2，133.6？±47.4×mg / dl和7.4？±1.1。术后第5天的平均血糖水平为88.0？±16.3？mg / dl（中值：84×mg / dl）（p <。001）。 51例患者中有59例改善了血糖控制。结论它值得注意的是，无论体重减轻，LSG是否可以在短期内对血糖水平控制血糖水平。因此，在治疗肥胖相关的T2DM的早期阶段，LSG应优选LSG，以防止与T2DM相关的并发症。

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