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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >The impact of obesity on severe disease and mortality in people with SARS‐CoV‐2: A systematic review and meta‐analysis
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The impact of obesity on severe disease and mortality in people with SARS‐CoV‐2: A systematic review and meta‐analysis

机译：肥胖对SARS-COV-2人的严重疾病和死亡率的影响：系统审查和荟萃分析

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Background Obesity accompanied by excess ectopic fat storage has been postulated as a risk factor for severe disease in people with SARS‐CoV‐2 through the stimulation of inflammation, functional immunologic deficit and a pro‐thrombotic disseminated intravascular coagulation with associated high rates of venous thromboembolism. Methods Observational studies in COVID‐19 patients reporting data on raised body mass index at admission and associated clinical outcomes were identified from MEDLINE, Embase, Web of Science and the Cochrane Library up to 16 May 2020. Mean differences and relative risks (RR) with 95% confidence intervals (CIs) were aggregated using random effects models. Results Eight retrospective cohort studies and one cohort prospective cohort study with data on of 4,920 patients with COVID‐19 were eligible. Comparing BMI?≥?25 vs ?35 vs 25?kg/m 2 was 7.04 (2.72‐18.20). High levels of statistical heterogeneity were partly explained by age; BMI?≥?25?kg/m 2 was associated with an increased risk of severe illness in older age groups (≥60?years), whereas the association was weaker in younger age groups (60?years). Conclusions Excess adiposity is a risk factor for severe disease and mortality in people with SARS‐CoV‐2 infection. This was particularly pronounced in people 60 and older. The increased risk of worse outcomes from SARS‐CoV‐2 infection in people with excess adiposity should be taken into account when considering individual and population risks and when deciding on which groups to target for public health messaging on prevention and detection measures. Systematic review registration: PROSPERO 2020: CRD42020179783.
机译：背景技术肥胖症伴有过量异位脂肪储存已被假定为SARS-COV-2的严重疾病的危险因素，通过刺激炎症，功能性免疫缺陷和血栓形成血管内血管凝血与相关高静脉血栓栓塞栓塞的血管内凝固。方法鉴定Covid-19患者的观察性研究从2020年5月16日的Medline，Embase，Science，Cochrane图书馆鉴定了关于加入和相关临床结果的提高体重指数数据的报告数据。平均差异和相对风险（RR）使用随机效果模型聚集95％置信区间（CIS）。结果八项回顾性队列研究与一对伙伴前瞻性队列研究与4,920名Covid-19患者的数据有资格。比较BMI？≥？25 Vs？35 Vs＆ 25 k 25？kg / m 2为7.04（2.72-18.20）。统计异质性的高水平均由年龄解释; BMI？≥？25？kg / m 2与老年人群体中严重疾病的风险增加有关（≥60岁），而该协会在较年轻的群体中较弱（60岁）。结论过度肥胖是SARS-COV-2感染的严重疾病和死亡率的危险因素。这是60人和60岁以上的人特别明显。在考虑个人和人口风险的情况下，应考虑到过度肥胖的人的SARS-COV-2感染的较差的较差的风险增加。系统审查注册：Prospero 2020：CRD42020179783。

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