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首页> 外文期刊>Mayo Clinic Proceedings: Innovations, Quality & Outcomes >Lung Function and Symptoms in Post–COVID-19 Patients
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Lung Function and Symptoms in Post–COVID-19 Patients

机译：后Covid-19患者的肺功能和症状

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Objective To address the lack of information about clinical sequelae of coronavirus disease 2019 (COVID-19). Patients and Methods Previously hospitalized COVID-19 patients who were attending the outpatient clinic for post–COVID-19 patients (ASST Ovest Milanese, Magenta, Italy) were included in this retrospective study. They underwent blood draw for complete blood count, C-reactive protein, ferritin, D-dimer, and arterial blood gas analysis and chest high-resolution computed tomography (HRCT) scan. The primary endpoint was the assessment of blood gas exchanges after 3 months. Other endpoints included the assessment of symptoms and chest HRCT scan abnormalities and changes in inflammatory biomarkers after 3 months from hospital admission. Results Eighty-eight patients (n?= 65 men; 73.9%) were included. Admission arterial blood gas analysis showed hypoxia and hypocapnia and an arterial partial pressure of oxygen/fractional inspired oxygen ratio of 271.4 (interquartile range [IQR]: 238-304.7) mm Hg that greatly improved after 3 months (426.19 [IQR: 395.2-461.9] mm Hg, P .001). Forty percent of patients were still hypocapnic after 3 months. Inflammatory biomarkers dramatically improved after 3 months from hospitalization. Fever, resting dyspnea, and cough were common at hospital admission and improved after 3 months, when dyspnea on exertion and arthralgias arose. On chest HRCT scan, more than half of individuals still presented with interstitial involvement after 3 months. Positive correlations between the interstitial pattern at 3 months and dyspnea on admission were found. C-reactive protein at admission was positively associated with the presence of interstitial involvement at follow-up. The persistence of cough was associated with presence of bronchiectasis and consolidation on follow-up chest HRCT scan. Conclusion Whereas inflammatory biomarker levels normalized after 3 months, signs of lung damage persisted for a longer period. These findings support the need for implementing post–COVID-19 outpatient clinics to closely follow-up COVID-19 patients after hospitalization.
机译：目的解决2019年冠状病毒疾病临床后遗症的信息（Covid-19）。在此回顾性研究中，患者和方法以前住院治疗的Covid-19位于Covid-19患者的门诊诊所（Asst Ovest Milanese，Magenta，意大利）的患者被列入了这项回顾性研究。他们接受了完全血统计数，C反应蛋白，铁蛋白，D-二聚体和动脉血气体分析和胸部高分辨率计算断层扫描（HRCT）扫描的血液绘制。主要终点是3个月后对血液燃气交换的评估。其他端点包括评估症状和胸部HRCT扫描异常，并在3个月内入院后3个月后炎症生物标志物的变化。结果八十八名患者（N？= 65人; 73.9％）。入学动脉血气分析显示缺氧和缺钙和氧气/分数激发氧比的动脉部分压力为271.4（间环尺寸[IQR]：238-304.7）mm Hg，在3个月后大大改善（426.19 [IQR：395.2-461.9 ] mm hg，p＆ .001）。 3个月后，40％的患者仍然是缺钙。炎症生物标志物在住院时间3个月后显着改善。发烧，休息呼吸困难和咳嗽在医院入院时常见，3个月后常见，当时呼吸困难和关节缩小症。在胸部HRCT扫描上，超过一半的人仍然在3个月后仍然具有间质上的参与。发现3个月间隙模式与入院呼吸困难之间的正相关性。入院时的C-反应蛋白与随访中的间质累及的存在呈正相关。咳嗽的持续存在与支气管扩张的存在和随访胸部HRCT扫描的巩固有关。结论虽然炎性生物标志物含量在3个月后归一化，肺部损伤的迹象持续更长。这些调查结果支持在住院后，在住院后对Covid-19外门诊诊所进行密切关注的Covid-19患者。

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