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首页> 外文期刊>Histopathology: Official Journal of the British Division of the International Academy of Pathology >Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction
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Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction

机译：Covid-19患者的后期检查揭示了肺部和其他器官的严重毛细血管充血和血管功能障碍的严重毛细血管血糖和血管功能障碍的弥漫性肺泡损伤

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Aims Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly evolved into a sweeping pandemic. Its major manifestation is in the respiratory tract, and the general extent of organ involvement and the microscopic changes in the lungs remain insufficiently characterised. Autopsies are essential to elucidate COVID-19-associated organ alterations. Methods and results This article reports the autopsy findings of 21 COVID-19 patients hospitalised at the University Hospital Basel and at the Cantonal Hospital Baselland, Switzerland. Anin-corporetechnique was performed to ensure optimal staff safety. The primary cause of death was respiratory failure with exudative diffuse alveolar damage and massive capillary congestion, often accompanied by microthrombi despite anticoagulation. Ten cases showed superimposed bronchopneumonia. Further findings included pulmonary embolism (n = 4), alveolar haemorrhage (n = 3), and vasculitis (n = 1). Pathologies in other organ systems were predominantly attributable to shock; three patients showed signs of generalised and five of pulmonary thrombotic microangiopathy. Six patients were diagnosed with senile cardiac amyloidosis upon autopsy. Most patients suffered from one or more comorbidities (hypertension, obesity, cardiovascular diseases, and diabetes mellitus). Additionally, there was an overall predominance of males and individuals with blood group A (81% and 65%, respectively). All relevant histological slides are linked as open-source scans in supplementary files. Conclusions This study provides an overview of postmortem findings in COVID-19 cases, implying that hypertensive, elderly, obese, male individuals with severe cardiovascular comorbidities as well as those with blood group A may have a lower threshold of tolerance for COVID-19. This provides a pathophysiological explanation for higher mortality rates among these patients.
机译：目的是由严重急性呼吸综合征冠状病毒2（SARS-COV-2）引起的冠状病毒疾病2019（Covid-19），迅速发展成为一种席卷的大流行。其主要表现在呼吸道中，并且器官受累的一般程度和肺部的微观变化仍然存在特征。尸检对于阐明Covid-19相关器官改变至关重要。方法和结果本文报告了21例Covid-19患者在大学医院巴塞尔和瑞士州州立古老医院的尸检患者的尸检调查结果。 anin-corporetechnique是为了确保最佳的员工安全。死亡的主要原因是呼吸失败，渗透性弥漫性肺泡损伤和大量毛细血管充血，尽管抗凝，通常伴有Microcroctrombi。十例呈现叠加的支气管内。进一步的发现包括肺栓塞（n = 4），肺泡出血（n = 3）和血管炎（n = 1）。其他器官系统的病理学主要是令人震惊的;三名患者显示出广义的迹象和五种肺血栓形成微扰动。在尸检时诊断出六名患者患有老年心肌淀粉样蛋白病。大多数患者患有一种或多种患者（高血压，肥胖，心血管疾病和糖尿病）。此外，血液组和分别存在血液组（分别为81％和65％）的总体优势。所有相关的组织学幻灯片都在补充文件中链接为开源扫描。结论本研究概述了Covid-19案例中的后期结果，暗示高血压，老年人，肥胖，男性个体，具有严重的心血管合并症的男性，以及具有血液组A的血管组可能具有较低的Covid-19耐受性的较低阈值。这为这些患者之间的死亡率提高了致病生理解释。

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