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首页> 外文期刊>Developmental cognitive neuroscience. >Functional connectivity of the attention networks is altered and relates to neuropsychological outcomes in children with prenatal alcohol exposure
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Functional connectivity of the attention networks is altered and relates to neuropsychological outcomes in children with prenatal alcohol exposure

机译：注意网络的功能连接被改变，并涉及产前酒精暴露的儿童的神经心理学结果

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Cognitive and functional brain alterations can occur in children with prenatal alcohol exposure (PAE). We examined the functional connectivity (FC) among regions within and between attention networks, and whether inter- and intranetwork FC moderated cognition in children with PAE ( n = 37; age 12.8 ± 2.8 years) and nonexposed controls ( n = 40; age 13.2 ± 2.8 years). Participants completed standardized attention and executive functioning tasks and resting state functional MRI. Inter- and intra-network FC and graph-theoretical metrics were calculated among attention network regions. Relative to controls, PAE was associated with reduced FC between the left temporoparietal junction and left ventral frontal cortex and anterior insula/frontal operculum (aI/fO), and between the left intraparietal sulcus and bilateral aI/fO. PAE was associated with increased FC between the right precuneus and intraparietal lobes, the right anterior prefrontal cortex and left ventral frontal cortex and aI/fO, and the left thalamus and dorsal frontal cortex. Graph-theoretical metrics did not differ by group. FC predicted cognitive performance, negatively in the children with PAE and positively in controls. Increased intra-network together with reduced internetwork FC suggests inefficient network specialization and impaired long-range FC among attention network regions after PAE. Results further suggest that those alterations may underlie attention and executive dysfunction in children with PAE.
机译：在产前酒精暴露（PAE）的儿童中可以发生认知和功能性脑改变。我们在注意网络内和之间的地区和intranetwork患者之间进行了职能连通性（FC），以及PAE儿童的间歇性和intranetwork患儿（n = 37;年龄12.8±2.8岁）和非爆炸控制（n = 40;年龄13.2岁±2.8岁）。参与者完成了标准化的关注和执行功能任务和休息状态功能MRI。在关注网络区域中计算了网络间和网络间FC和图形理论度量。相对于对照，PAE与左侧颞淀粉和左侧腹部连续式（AI / FO）之间的左侧颞淀粉和左侧肠道/正面孔（AI / FO）之间的降低相关，并且在左内血管和双侧AI / FO之间。 PAE与右前列叶片和片内裂片之间的Fc增加有关，右前额前皮层和左侧腹部皮质和Ai / Fo，以及左丘脑和背部额面皮质。图形 - 理论度量指标没有差异。 FC预测认知性能，对PAE的儿童和积极控制的儿童负面。随着互联网FC的减少，网络内部网络的增加表明，PAE之后，关注网络区域中的远程FC效率低下。结果进一步表明，这些改变可能借着PAE的儿童注意力和行政功能障碍。

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