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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Association of Oral Melanosis with Soft Tissue Pathologies: A Hospital Based Observational Study
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Association of Oral Melanosis with Soft Tissue Pathologies: A Hospital Based Observational Study

机译：口腔黑色素病与软组织病理学协会：基于医院的观察研究

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Oral pigmentation can be physiological/pathological, exogenous/endogenous. Melanin is the most important pigment responsible for normal pigmentation. Recent increasing evidence shows that melanosis occurs in many oral soft tissue pathologies.Aim: To assess the pigmentation in various oral soft tissue lesions with that of normal oral mucosa.Materials and Methods: An observational study was conducted at Maulana Azad Institute of Dental Sciences, New Delhi, India, for a period of six months. A total of 805 study participants were included in the study population. Among these, 605 study participants with soft tissue pathologies with or without tobacco habits were cases and 200 study participants without any pathology and habit comprised controls. Assessment of oral melanosis was done at various sites within the oral cavity. Prevalence of melanosis with oral lesions and habits were estimated using Statistical Package for the Social Sciences (SPSS) statistical software (version 16.0).Results: Out of 605, 280 cases (46.28%) whereas out of 200, 54 controls (27%) showed melanosis which was statistically significant. Melanosis was most prevalent in men, in the age group of 21-40 years predominantly involving the buccal mucosa. Maximum cases presenting melanosis were amongst smoked tobacco users and with both tobacco habits were found in leukoplakia (37.7% and 28.3%, respectively). However, 74.2% smokeless tobacco users with melanosis showed Oral Submucous Fibrosis (OSMF) which was statistically significant.Conclusion: Various forms of tobacco consumption commonly induce intra mucosal pigmentation which could be due to high chemical and mechanical irritation by tobacco. The study attempts to assess the overall prevalence of melanosis in study participants with pathologies and habits to understand the implications of melanosis in pathologies in the general population.
机译：口服色素沉着可以是生理/病理，外源/内源性。黑色素是最重要的颜料，负责正常色素沉着。最近的越来越多的证据表明，黑色素病发生在许多口腔软组织病理中。评估具有正常口腔粘膜的各种口腔软组织病变中的色素沉着。材料和方法：在Maulana Azad牙科科学研究所进行了一个观察研究，新德里，印度，六个月的时间。研究人群共有805名研究参与者。其中，605项研究参与者具有或没有烟草习惯的软组织病理学是病例，200名研究参与者没有任何病理学和习性构成对照。在口腔内的各个部位进行口腔黑色素病评估。利用口腔病变和习惯的患病率使用统计包（SPSS）统计软件（16.0版）。结果显示了统计学意义的黑色素病。黑色素病在男性中最普遍，在21-40岁的年龄组中，主要涉及口腔粘膜。最大案例呈现黑色素的烟草烟草中的烟草中，烟草习惯都被发现在菌片中（分别为37.7％和28.3％）。然而，74.2％的无烟烟草烟草用黑色素病症显示出统计学显着的口腔粘膜纤维化（OSMF）。结论：各种形式的烟草消耗通常诱导粘膜中的粘膜色素沉着，这可能是由于烟草的高化学和机械刺激。该研究试图评估学习参与者的含有病理学和习惯的黑心素病的整体患病率，以了解一般人群在病理中对黑解剖学的影响。

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