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Vitamin D prophylaxis in infancy

机译：婴儿期的维生素D预防

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We looked at existing recommendations and supporting evidence on the effectiveness of vitamin D supplementation in infancy for reducing vitamin D deficiency and for preventing rickets and infections. We also looked at optimal dose of vitamin D and the age until which vitamin D supplementation is beneficial.We conducted a literature search up to the 17th of July 2019 by using key terms and manual search in selected sources. We summarized the recommendations and the strength of the recommendation when and as reported by the authors. We summarized the main findings of systematic reviews with the certainty of the evidence as reported.A daily dose of 400 international units of vitamin D in infants has shown to be effective for improving bone health and preventing rickets. Evidence is more robust in groups of infants and children at risk. Vitamin D supplementation is well tolerated, and not associated with toxicity. Higher doses have not shown to add benefit while it could potentially cause toxic blood levels and hypercalcemia. Adequate levels of vitamin D might not be achieved with lower daily doses. Universal vitamin D supplementation starting shortly after birth, regardless of the mode of feeding and until 12?months of age, is strongly recommended. Beyond 12?months of age vitamin D supplementation is recommended only in groups of children at risk.
机译：我们研究了关于维生素D补充初期血液缺乏的有效性的现有建议和支持证据，用于减少维生素D缺乏，防止佝偻病和感染。我们还研究了最佳剂量的维生素D和年龄，直到维生素D补充是有益的。我们通过在所选来源中使用关键条款和手动搜索，在2019年7月17日进行了文献搜索。我们总结了提交人报告的建议和建议的建议。我们总结了系统性审查的主要发现，符合报告的证据。婴儿的每日剂量为400个国际维生素D单位，对改善骨骼健康和预防佝偻病有效。证据对风险的婴儿和儿童组织更加强大。维生素D补充是良好的耐受性，而不与毒性有关。较高的剂量未显示在可能导致有毒血液水平和高钙血症时添加益处。每月剂量降低，可能无法实现足够的维生素D水平。普遍的维生素D在出生后不久起的补充，无论喂养模式如何，都强烈建议。超过12月的维生素D补充剂，仅供患有风险的儿童组。

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