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首页> 外文期刊>Journal of experimental & clinical cancer research : >A review of Dynamin 2 involvement in cancers highlights a promising therapeutic target
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A review of Dynamin 2 involvement in cancers highlights a promising therapeutic target

机译：对Dynamin 2参与癌症的综述突出了一个有前途的治疗目标

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Dynamin 2 (DNM2) is an ubiquitously expressed large GTPase well known for its role in vesicle formation in endocytosis and intracellular membrane trafficking also acting as a regulator of cytoskeletons. During the last two decades, DNM2 involvement, through mutations or overexpression, emerged in an increasing number of cancers and often associated with poor prognosis. A wide panel of DNM2-dependent processes was described in cancer cells which explains DNM2 contribution to cancer pathomechanisms. First, DNM2 dysfunction may promote cell migration, invasion and metastasis. Second, DNM2 acts on intracellular signaling pathways fostering tumor cell proliferation and survival. Relative to these roles, DNM2 was demonstrated as a therapeutic target able to reduce cell proliferation, induce apoptosis, and reduce the invasive phenotype in a wide range of cancer cells in vitro. Moreover, proofs of concept of therapy by modulation of DNM2 expression was also achieved in vivo in several animal models. Consequently, DNM2 appears as a promising molecular target for the development of anti-invasive agents and the already provided proofs of concept in animal models represent an important step of preclinical development.
机译：发电机2（DNM2）是一种普遍地表达大型GTP酶，其众所周知，其在内吞作用中的囊泡形成和细胞内膜运输中也作用为细胞骨架的调节剂。在过去的二十年中，DNM2参与通过突变或过度表达在越来越多的癌症中出现并且通常与预后差有关。在癌细胞中描述了宽面板的DNM2依赖性方法，该细胞描述了DNM2对癌症土地机制的贡献。首先，DNM2功能障碍可以促进细胞迁移，侵袭和转移。其次，DNM2作用于培养肿瘤细胞增殖和存活的细胞内信号传导途径。相对于这些作用，DNM2被证明作为能够降低细胞增殖，诱导细胞凋亡的治疗靶，并在体外减少各种癌细胞中的侵入性表型。此外，通过调节DNM2表达的治疗概念的证据也在几种动物模型中进行了体内。因此，DNM2作为抗侵袭剂的发展的有希望的分子靶标，并且在动物模型中已经提供的概念证据代表了临床前发育的重要步骤。

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