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首页> 外文期刊>BMC Genomics >Genome collinearity analysis illuminates the evolution of donkey chromosome 1 and horse chromosome 5 in perissodactyls: A comparative study
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Genome collinearity analysis illuminates the evolution of donkey chromosome 1 and horse chromosome 5 in perissodactyls: A comparative study

机译：基因组共同性分析照亮促甲状腺蛋白酶乳染色体1和马染色体5的演变：比较研究

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It is important to resolve the evolutionary history of species genomes as it has affected both genome organization and chromosomal architecture. The rapid innovation in sequencing technologies and the improvement in assembly algorithms have enabled the creation of highly contiguous genomes. DNA Zoo, a global organization dedicated to animal conservation, offers more than 150 chromosome-length genome assemblies. This database has great potential in the comparative genomics field. Using the donkey (Equus asinus asinus, EAS) genome provided by DNA Zoo as an example, the scaffold N50 length and Benchmarking Universal Single-Copy Ortholog score reached 95.5?Mb and 91.6%, respectively. We identified the cytogenetic nomenclature, corrected the direction of the chromosome-length sequence of the donkey genome, analyzed the genome-wide chromosomal rearrangements between the donkey and horse, and illustrated the evolution of the donkey chromosome 1 and horse chromosome 5 in perissodactyls. The donkey genome provided by DNA Zoo has relatively good continuity and integrity. Sequence-based comparative genomic analyses are useful for chromosome evolution research. Several previously published chromosome painting results can be used to identify the cytogenetic nomenclature and correct the direction of the chromosome-length sequence of new assemblies. Compared with the horse genome, the donkey chromosomes 1, 4, 20, and X have several obvious inversions, consistent with the results of previous studies. A?4.8?Mb inverted structure was first discovered in the donkey chromosome 25 and plains zebra chromosome 11. We speculate that the inverted structure and the tandem fusion of horse chromosome 31 and 4 are common features of non-caballine equids, which supports the correctness of the existing Equus phylogeny to an extent.
机译：重要的是解决物种基因组的进化史，因为它影响了基因组组织和染色体建筑。测序技术的快速创新和装配算法的改进使得能够产生高度连续的基因组。 DNA动物园是一种致力于动物保护的全球组织，提供了超过150个染色体长度基因组组件。该数据库在比较基因组学领域具有很大的潜力。使用DNA动物园提供的驴（Equus Asinus Asinus，EAS）基因组作为示例，脚手架N50长度和基准，分别达到95.5？MB和91.6％。我们鉴定了细胞遗传学命名法，纠正了驴基因组的染色体长度序列的方向，分析了驴和马之间的基因组染色体重排，并说明了雌激散蛋白的甜染染色体1和马染色体5的演变。 DNA动物园提供的驴基因组具有相对良好的连续性和完整性。基于序列的比较基因组分析可用于染色体进化研究。几种先前公布的染色体涂料结果可用于鉴定细胞遗传学命名法并校正新组件的染色体长度序列的方向。与马基因组相比，驴染色体1,4,20和X具有若干明显的逆转，与先前研究的结果一致。 a 4.8？MB倒置结构首先在驴染色体25中发现，平原斑马染色体11.我们推测了马染色体31和4的倒置结构和串联融合是非锦缎等式的常见特征，支持正确性现有的平衡系统在某种程度上。

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