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首页> 外文期刊>Journal of International Medical Research >Levels of endoplasmic reticulum stress-related mRNA in peritoneal fluid of patients with endometriosis or gynaecological cancer
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Levels of endoplasmic reticulum stress-related mRNA in peritoneal fluid of patients with endometriosis or gynaecological cancer

机译：子宫内膜异位病或妇科癌症患者腹膜液中的内质网胁迫相关mRNA水平

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Objective To compare the levels of endoplasmic reticulum (ER) stress-associated mRNAs and the clinical characteristics of patients with endometriosis or gynaecological cancer. Methods This prospective study obtained intraperitoneal fluid samples from female patients that underwent surgery. The levels of ER stress mRNAs in the peritoneal fluid, including C/EBP-homologous protein (CHOP), X-box binding protein 1 (sXBP1), activating transcription factor 6 (ATF6), immunoglobulin heavy chain-binding protein (BiP), inositol-requiring enzyme 1α (IRE1α) and protein kinase RNA-like endoplasmic reticulum kinase (PERK), were measured using real-time reverse transcription–polymerase chain reaction in patients with benign disease without endometriosis (control group), with endometriosis or with gynaecological cancer. Results This study enrolled 126 patients: 46 control patients; 47 with endometriosis; and 33 with cancer. The levels of CHOP and BiP mRNA were significantly higher in the control group compared with the cancer group. Levels of sXBP1 and ATF6 mRNA were significantly higher in the cancer group than in the control and endometriosis groups. In the endometriosis group, ATF6 mRNA level was inversely correlated with age and positively correlated with serum cancer antigen 125 levels; and ATF6 and PERK mRNA levels were inversely correlated with parity. Conclusion The levels of ER stress-related mRNAs were related to the pathogenesis of endometriosis and gynaecological cancers.
机译：目的比较内质子（ER）应激相关MRNA的水平和子宫内膜异位症或妇科癌症患者的临床特征。方法该前瞻性研究从医生接受手术的患者中获得腹膜内液样品。 ER应激MRNA在腹膜液中的水平，包括C / EBP-同源蛋白（CHPO），X箱结合蛋白1（SXBP1），激活转录因子6（ATF6），免疫球蛋白重链结合蛋白（BIP），需要肌醇酶1α（IRE1α）和蛋白激酶RNA样内质网激酶（PERK），在没有子宫内膜异位症（对照组），子宫内膜异位症或妇科的患者中使用实时逆转录 - 聚合酶链反应测量。癌症。结果本研究注册了126名患者：46名控制患者; 47具有子宫内膜异位症;和33带癌症。对照组与癌症组相比，对照组的碎片和BIP mRNA水平显着较高。癌组的SXBP1和ATF6 mRNA水平显着高于对照和子宫内膜异位症组。在子宫内膜异位荧光病组中，ATF6 mRNA水平与年龄与年龄和与血清癌抗原125水平呈正相关; ATF6和PERK mRNA水平与平价相反。结论ER应激相关的MRNA水平与子宫内膜异位症和妇科癌症的发病机制有关。

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