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首页> 美国卫生研究院文献>European Journal of Obstetrics Gynecology and Reproductive Biology: X >Differences in autophagy-associated mRNAs in peritoneal fluid of patients with endometriosis and gynecologic cancers
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Differences in autophagy-associated mRNAs in peritoneal fluid of patients with endometriosis and gynecologic cancers

机译：子宫内膜异位症和妇科癌症患者腹膜液中自噬相关mRNA的差异

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Endometriosis and gynecologic cancer show similar patterns of invasion. Little is known about the roles of autophagy in endometriosis and, to date, the expression of autophagy-associated mRNAs has not been compared in patients with endometriosis and gynecologic cancers. This study therefore compared the levels of expression of autophagy-associated mRNAs in patients with endometriosis and gynecologic cancers. The levels of autophagy mRNAs, including those encoding mTOR, P13KC3, Beclin-1, Bcl-2, LC3 II, FLIP, Rubicon, BIRC2 and BIRC5, were measured by real time polymerase chain reaction in peritoneal fluid of 27 patients with benign masses (control group), 42 patients with endometriosis, and 43 patients with gynecologic (ovarian, uterine, and cervical) cancers. Findings in the three groups were compared. Autophagy mRNAs were present in all samples from patients with endometriosis and gynecologic cancers. The levels of PI3K, FLIP, and Rubicon mRNAs were significantly higher in the endometriosis than in the control group (p < 0.05 each). Compared with the gynecologic cancer group, the levels of LC3II and FLIP mRNAs were significantly lower, and the levels of Beclin-1 and Rubicon mRNAs significantly higher, in the endometriosis group (p < 0.05 each). Levels of PI3K and FLIP mRNA were significantly higher in the endometriosis and gynecologic cancer groups than in the control group (p < 0.05 each). PI3K, FLIP, and Rubicon mRNAs are closely associated with the pathogenesis of endometriosis. The similar increases in PI3K and FLIP mRNA expression observed in patients with endometriosis and gynecologic cancer suggest that these conditions have similar autophagic characteristics. The lower levels of Beclin-1 mRNA in the gynecologic cancer than in other two groups suggest that lower Beclin-1 mRNA levels increase the likelihood of developing gynecologic cancer.
机译：子宫内膜异位症和妇科癌表现出相似的浸润模式。关于自噬在子宫内膜异位症中的作用知之甚少，迄今为止，尚未在患有子宫内膜异位症和妇科癌症的患者中比较自噬相关mRNA的表达。因此，本研究比较了子宫内膜异位症和妇科癌症患者自噬相关mRNA的表达水平。通过实时聚合酶链反应在27例良性肿块患者的腹膜液中测量自噬mRNA的水平，包括编码mTOR，P13KC3，Beclin-1，Bcl-2，LC3 II，FLIP，Rubicon，BIRC2和BIRC5的mRNA（对照组），42例子宫内膜异位患者和43例妇科（卵巢癌，子宫癌和宫颈癌）患者。比较了三组的发现。自体子宫内膜异位症和妇科癌症患者的所有样品中均存在自噬mRNA。子宫内膜异位症中PI3K，FLIP和Rubicon mRNA的水平显着高于对照组（每个p <0.05）。与子宫内膜异位症组相比，与妇科癌症组相比，LC3II和FLIP mRNA水平显着降低，Beclin-1和Rubicon mRNA水平显着升高（p <0.05）。子宫内膜异位症和妇科癌症组的PI3K和FLIP mRNA水平显着高于对照组（每组P 0.05）。 PI3K，FLIP和Rubicon mRNA与子宫内膜异位症的发病机理密切相关。在子宫内膜异位症和妇科癌症患者中观察到的PI3K和FLIP mRNA表达的相似增加表明这些疾病具有相似的自噬特征。妇科癌症中Beclin-1 mRNA的水平低于其他两组，这表明较低的Beclin-1 mRNA水平增加了发展妇科癌症的可能性。

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