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首页> 外文期刊>Diabetes >Risk Factor Modeling for Cardiovascular Disease in Type 1 Diabetes in the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study: A Comparison With the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC)
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Risk Factor Modeling for Cardiovascular Disease in Type 1 Diabetes in the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study: A Comparison With the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC)

机译：匹兹堡糖尿病并发症流行病学（EDC）研究中1型糖尿病心血管疾病的危险因素建模：与糖尿病控制和并发症的比较糖尿病干预和并发症研究/流行病学研究（DCCT / EDIC）

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摘要

In a recent Diabetes Control and Complications Trial (DCCTJ/Epidemiology of Diabetes Interventions and Complications (EDIC) study report, mean HbA_(1c) was the strongest predictor of cardiovascular disease (CVD) after age. In DCCT/EDIC, mean diabetes duration was 6 years (median 4) at baseline and those with high blood pressure or cholesterol were excluded. We now replicate these analyses in the Pittsburgh Epidemiology of Diabetes Complications (EDC) prospective cohort study of childhood-onset (at <17 years of age) type 1 diabetes, with similar age (mean 27 years in both studies) but longer diabetes duration (mean 19 years and median 18 years) and no CVD risk factor exclusion at baseline. CVD incidence (CVD death, myocardial infarction (Ml), stroke, revascularization, angina, or ischemic electrocardiogram) was associated with diabetes duration, most recent albumin excretion rate (AER), updated mean triglycerides, baseline hypertension, baseline LDL cholesterol, and most recent HbA_(1c). Major atherosclerotic cardiovascular events (CVD death, Ml, or stroke) were associated with diabetes duration, most recent AER, baseline systolic blood pressure, baseline smoking, and updated mean HbA_(1c). Compared with findings in DCCT/ EDIC, traditional risk factors similarly predicted CVD; however AER predominates in EDC and HbA_(1c) in DCCT/EDIC. Thus, the relative impact of HbA_(1c) and kidney disease in type 1 diabetes varies according to diabetes duration.
机译：在最近的糖尿病控制与并发症试验（DCCTJ /糖尿病干预与并发症流行病学）（EDIC）研究报告中，平均HbA_（1c）是年龄后心血管疾病（CVD）的最强预测因子。基线为6年（中位数4）和高血压或胆固醇人群被排除在外，我们现在在匹兹堡糖尿病并发症流行病学（EDC）儿童期（<17岁）类型前瞻性队列研究中重复这些分析1例糖尿病，年龄相似（两项研究中平均为27岁），但糖尿病持续时间较长（平均19岁，中位18岁），基线时无CVD危险因素被排除。CVD发生率（CVD死亡，心肌梗死（M1），中风，血运重建，心绞痛或缺血性心电图）与糖尿病病程，最新白蛋白排泄率（AER），更新的平均甘油三酸酯，基线高血压，基线LDL胆固醇和最新HbA_（1c）相关。主要的动脉粥样硬化性心血管事件（CVD死亡，MI或中风）与糖尿病病程，最近的AER，基线收缩压，基线吸烟和平均HbA_（1c）相关。与DCCT / EDIC中的发现相比，传统的危险因素同样预测CVD。然而，在DCC / EDIC中，AER在EDC和HbA_（1c）中占主导地位。因此，HbA_（1c）与1型糖尿病患者肾脏疾病的相对影响因糖尿病病程而异。

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  • 来源
    《Diabetes》 |2019年第2期|409-419|共11页
  • 作者

    Rachel G. Miller; Tina Costacou; Trevor J. Orchard;

  • 作者单位

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA;

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA;

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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