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首页> 外文期刊>Digestive Diseases and Sciences >Intestinal 5-Hydroxytryptamine and Mast Cell Infiltration in Rat Experimental Colitis
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Intestinal 5-Hydroxytryptamine and Mast Cell Infiltration in Rat Experimental Colitis

机译：大鼠实验性结肠炎的肠道5-羟色胺和肥大细胞浸润

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The present study evaluated the extent of dysfunction of the 5-hydroxytryptaminergic system in inflamed (distal colon) and noninflamed segments (jejunum and ileum) after intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in the rat. Dexamethasone was administered to control rats and TNBS-treated animals before and for 7 days after TNBS treatment. Tissue levels of 5-hydroxytryptamine (5-HT) in the inflamed colon were higher than in controls. The densitmast cells was also markedly increased. Treatment with dexamethasone attenuated the inflammatory response but did not prevent the increase in colonic 5-HT. In the noninflamed jejunum and terminal ileum, 5-HT tissue levels were markedly increased, but treatment with dexamethasone prevented this increase. It is concluded that the increase in 5-HT levels in the inflamed colon in TNBS-induced colitis may result fmast cell infiltration. In the noninflamed intestine, 5-HT tissue levels were also increased, favoring the view of a generalized mast cell infiltration.
机译：本研究评估了大鼠直肠内施用2,4,6-三硝基苯磺酸（TNBS）后发炎（远端结肠）和非发炎片段（空肠和回肠）中的5-羟色胺能系统功能障碍的程度。在TNBS治疗之前和之后7天，将地塞米松用于对照大鼠和TNBS处理的动物。发炎的结肠中5-羟色胺（5-HT）的组织水平高于对照组。致密度细胞也明显增加。地塞米松治疗可减轻炎症反应，但不能阻止结肠5-HT升高。在非发炎的空肠和回肠末端，5-HT组织水平显着增加，但是地塞米松治疗阻止了这种增加。结论是在TNBS诱发的结肠炎中发炎的结肠中5-HT含量的升高可能导致原发性细胞浸润。在非发炎的肠中，5-HT组织水平也增加，有利于广泛性肥大细胞浸润的观点。

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