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首页> 外文期刊>Digestive Diseases and Sciences >Prevalence of Non-Organ-Specific Autoantibodies in Patients Suffering from Duodenal Ulcer With and Without Helicobacter pylori Infection
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Prevalence of Non-Organ-Specific Autoantibodies in Patients Suffering from Duodenal Ulcer With and Without Helicobacter pylori Infection

机译：患有和不患有幽门螺杆菌感染的十二指肠溃疡患者中非器官特异性自身抗体的患病率

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摘要

Autoimmunity, a feature of chronic infection by Helicobacter pylori, is first directed against gastric cells but is also associated with extragastric diseases. The aim of the present work was to look for the influence of the infection on induction of non-organ-specific autoantibodies (NOSAs). We compared 49 patients (28 males and 21 females; age range, 36–72 years; mean, 61 ± 4.6 years) suffering from duodenal ulcer and H. pylori infection (Group A) to 38 subjects (20 male, 18 female; age range, 40–78 years; mean, 63 ± 3.8 years) affected by duodenal ulcer related to the assumption of nonsteroidal antiinflammatory drugs (Group B). H. pylori infection was diagnosed by histology, 13C-urea breath test, and serum IgG antibodies. Autoimmunitary pattern was demonstrated by the presence of NOSAs in serum. Antinuclear (ANA), anti-smooth muscle (SMA), and anti-liver/kidney microsomal-1 (LKM-1) antibodies were present in 5 of 49 (10.2%), 2 of 49 (4%), and 0 Group A patients, respectively. In Group B, ANA was present in 3 of 38 (7.9%), SMA in 3 of 38 (7.9%), and anti-LKM-1 in 0 patients. The difference was not statistically significant. In this population, H. pylori infection is not associated with an increased prevalence of NOSAs.
机译：自身免疫是幽门螺杆菌慢性感染的特征，首先针对胃细胞，但也与胃外疾病有关。本工作的目的是寻找感染对非器官特异性自身抗体（NOSA）诱导的影响。我们比较了38名受试者（男20例，女18例；年龄：36岁至72岁；平均年龄61±4.6岁）的十二指肠溃疡和幽门螺杆菌感染（A组）的49例患者（男性）范围为40-78岁；平均63±3.8岁）受与非甾体类抗炎药使用相关的十二指肠溃疡的影响（B组）。幽门螺杆菌感染通过组织学，13 C-尿素呼气试验和血清IgG抗体进行诊断。血清中存在NOSA证明了自身免疫模式。 49个中的5个（10.2％），49个中的2个（4％）和0组中存在抗核（ANA），抗平滑肌（SMA）和抗肝/肾微粒体1（LKM-1）抗体一个病人，分别。在B组中，ANA在38例患者中占3（7.9％），SMA在38例患者中占3（7.9％），抗LKM-1在0例患者中。差异无统计学意义。在该人群中，幽门螺杆菌感染与NOSA患病率增加无关。

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