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首页> 外文期刊>Digestive Diseases and Sciences >Somatostatin Antagonism Prevents Elemental Diet-Induced Intestinal Atrophy in the Rat
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Somatostatin Antagonism Prevents Elemental Diet-Induced Intestinal Atrophy in the Rat

机译：生长抑素拮抗作用可防止元素饮食引起的大鼠肠道萎缩

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摘要

Somatostatin is a peptide with known antiproliferative effects on the intestine. The aim of the present work was to determine whether somatostatin (SST) antagonism reduces elemental diet-induced intestinal atrophy in the rat. Male Wistar rats were fed a standard diet and treated for seven days with either continuous infusion of saline or low and high doses of a putative somatostatin antagonist; another group was given a SST antagonist in a pulsatile high dose. All these groups received an elemental diet to induce gut mucosa atrophy. Rats were killed and samples were obtained for morphometric and proliferative measurements of the intestine and for SST and insulin-like growth factor-1 (IGF-1) level determination. The elemental diet decreased mucosal length and proliferation. Pulsatile administration of SST antagonist improved or prevented both effects, whereas continuous SST antagonist delivery prevented decreased crypt proliferation induced by the elemental diet. Somatostatin plasma levels were lowest in rats receiving pulsatile administration of SST antagonist. In conclusion, somatostatin antagonism increases proliferation in the intestinal mucosa, improving elemental diet-induced intestinal atrophy; however, morphological growth is not affected.
机译：生长抑素是一种对肠道具有已知抗增殖作用的肽。本研究的目的是确定生长抑素（SST）拮抗作用是否能减少大鼠饮食中元素饮食引起的肠道萎缩。给雄性Wistar大鼠喂食标准饮食，连续输注盐水或低剂量和高剂量推定的生长抑素拮抗剂治疗7天。另一组给予了高剂量的脉动性SST拮抗剂。所有这些组接受基本饮食以诱发肠粘膜萎缩。处死大鼠并获得样品以进行肠道的形态计量和增殖测定以及SST和胰岛素样生长因子-1（IGF-1）水平的测定。基本饮食减少了粘膜长度和增殖。 SST拮抗剂的脉冲给药改善或预防了这两种作用，而SST拮抗剂的连续输送阻止了元素饮食诱导的隐窝增生减少。在接受SST拮抗剂脉动给药的大鼠中，生长抑素血浆水平最低。总之，生长抑素拮抗作用可增加肠道粘膜的增殖，改善元素饮食引起的肠道萎缩。但是，形态生长不受影响。

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