• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Doklady biochemistry & biophysics >Development of Computational Methods to Search for FoxA Transcription Factor Binding Sites, Their Experimental Verification and Application to the Analysis of Chip-Seq Data
【24h】

Development of Computational Methods to Search for FoxA Transcription Factor Binding Sites, Their Experimental Verification and Application to the Analysis of Chip-Seq Data

机译：计算FoxA转录因子结合位点的计算方法的开发，它们的实验验证和在芯片序列数据分析中的应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Transcription factors of the FoxA family play a key role in early embryogenesis, organogenesis, and maintenance of metabolic homeostasis of the organism [ 1 ]. This family includes three proteins-FoxAl, FoxA2, and FoxA3-which contain a highly conserved DNA-binding domain and can interact with the same DNA sequences [2]. A characteristic feature of FoxA binding sites is their high variability, as a result of which the consensus sequence of these sites (VAWTRTTKRTY [3]) can be represented only in the form of 15-letter TUPAC code [4]. However, even in this form it does not describe all sites. In view of this, the development of computer methods for recognition of FoxA binding sites is an intricate problem.
机译：FoxA家族的转录因子在生物的早期胚胎发生，器官发生和代谢稳态中起着关键作用[1]。该家族包括三种蛋白-FoxAl，FoxA2和FoxA3，它们含有高度保守的DNA结合结构域，并且可以与相同的DNA序列相互作用[2]。 FoxA结合位点的一个特征是其高可变性，因此这些位点的共有序列（VAWTRTTKRTY [3]）只能以15个字母的TUPAC代码形式表示[4]。但是，即使采用这种形式，也无法描述所有站点。鉴于此，开发用于识别FoxA结合位点的计算机方法是一个复杂的问题。

著录项

  • 来源
    《Doklady biochemistry & biophysics》 |2011年第janaafeba期|p.12-15|共4页
  • 作者

    V. G. Levitsky; D. Yu. Oshchepkov; N. I. Ershov; L. O. Bryzgalov; E. V. Antontseva; G. V. Vasiliev; T. I. Merkulova; N. A. Kolchanov;

  • 作者单位

    Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences, pr. Akademika Lavrent'eva 10,Novosibirsk, 630090 Russia Novosibirsk State University, ul. Pirogova 2,Novosibirsk, 630090 Russia;

    Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences, pr. Akademika Lavrent'eva 10,Novosibirsk, 630090 Russia Novosibirsk State University, ul. Pirogova 2,Novosibirsk, 630090 Russia;

    Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences, pr. Akademika Lavrent'eva 10,Novosibirsk, 630090 Russia Novosibirsk State University, ul. Pirogova 2,Novosibirsk, 630090 Russia;

    Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences, pr. Akademika Lavrent'eva 10,Novosibirsk, 630090 Russia Novosibirsk State University, ul. Pirogova 2,Novosibirsk, 630090 Russia;

    Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences, pr. Akademika Lavrent'eva 10,Novosibirsk, 630090 Russia Novosibirsk State University, ul. Pirogova 2,Novosibirsk, 630090 Russia;

    Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences, pr. Akademika Lavrent'eva 10,Novosibirsk, 630090 Russia Novosibirsk State University, ul. Pirogova 2,Novosibirsk, 630090 Russia;

    Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences, pr. Akademika Lavrent'eva 10,Novosibirsk, 630090 Russia Novosibirsk State University, ul. Pirogova 2,Novosibirsk, 630090 Russia;

    Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences, pr. Akademika Lavrent'eva 10,Novosibirsk, 630090 Russia Novosibirsk State University, ul. Pirogova 2,Novosibirsk, 630090 Russia;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号