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首页> 外文期刊>Endocrine journal >Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control
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Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control

机译：糖化白蛋白（GA）和糖化血红蛋白（HbA1c）在2型糖尿病患者中的比较：遗传算法用于评估血糖控制短期变化的有用性

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We studied the cross-sectional relationship between GA and HbA1c in 142 type 2 diabetic patients who had an HbA 1c level < 7.5% for at least one year without fluctuation by more than 0.5%. We also followed the changes of GA and HbA1c in 18 type 2 diabetic patients for 16 weeks as they progressed from untreated severe hyperglycemia (HbA 1c ≥ 9.0%) to good glycemic control (HbA1c ≤ 6.5%) by intensive insulin treatment. The annual mean levels of GA and HbA1c in the stably controlled patients showed a weak, but significant, correlation (r = 0.23, p < 0.001) in the 142 diabetic patients. However, the GA/HbA 1c ratio ranged widely from 2.0 to 4.0 showing a normal distribution (2.9 ± 0.34, M ± SE), although patients with conditions affecting albumin turnover or RBC lifespan were excluded from the study. The GA/HbA1c ratio was significantly higher when patients were in hyperglycemic than when glycemic control was good (3.5 ± 0.15 vs. 2.9 ± 0.07, M ± SE, p < 0.01). GA decreased more rapidly than HbA1c during intensive insulin therapy, but the percent reduction of HbA1c eventually corresponded with that of GA by 16 weeks after the start of treatment. These results demonstrate that, although unknown influences on GA or HbA1c may exist, GA may be a useful marker for monitoring short-term variations of glycemic control during treatment of diabetic patients.
机译：我们研究了HbA 1c水平<7.5％的至少142名2型糖尿病患者中GA和HbA1c之间的横断面关系，至少一年，且波动不超过0.5％。我们还追踪了18位2型糖尿病患者中GA和HbA1c在16周内的变化，原因是他们从未经治疗的严重高血糖症（HbA 1c≥9.0％）发展为通过强化胰岛素治疗实现良好的血糖控制（HbA1c≤6.5％）。在142名糖尿病患者中，稳定控制的患者中GA和HbA1c的年平均水平显示出弱但显着的相关性（r = 0.23，p <0.001）。然而，GA / HbA 1c的比值范围从2.0到4.0呈正态分布（2.9±0.34，M±SE），尽管有影响白蛋白更新或RBC寿命的患者被排除在研究之外。高血糖患者的GA / HbA1c比显着高于血糖控制良好的患者（3.5±0.15 vs. 2.9±0.07，M±SE，p <0.01）。在强化胰岛素治疗期间，GA的下降速度比HbA1c更快，但是在开始治疗后16周，HbA1c的下降百分比最终与GA相对应。这些结果表明，尽管可能存在对GA或HbA1c的未知影响，但GA可能是监测糖尿病患者治疗期间血糖控制短期变化的有用标志物。

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